Before becoming HOSxP, the software was called KSK-HDBMS. Seeking a more friendly name, the development team opted for the name HOSxP, which comes from Hospital and Experience. The name also reflects the software's graphical user interface, which mimic the theme of Windows XP, no matter what actually the underlying operating system.
The development started in 1999. Emerged from a solo project by Chaiyaporn Suratemekul, a pharmacist by training, now main developers of the software are staffs from Bangkok Medical Software Co., Ltd., a company led by Chaiyaporn. The development infrastructure, including source code repository, is hosted by SourceForge.net.