HOXA3

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Homeobox A3
Identifiers
Symbols HOXA3 ; HOX1; HOX1E
External IDs OMIM142954 MGI96175 HomoloGene40725 GeneCards: HOXA3 Gene
RNA expression pattern
PBB GE HOXA3 208604 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3200 15400
Ensembl ENSG00000105997 ENSMUSG00000079560
UniProt O43365 P02831
RefSeq (mRNA) NM_030661 NM_010452
RefSeq (protein) NP_109377 NP_034582
Location (UCSC) Chr 7:
27.15 – 27.19 Mb
Chr 6:
52.17 – 52.21 Mb
PubMed search [1] [2]

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Regulation[edit]

The HOXA3 gene is repressed by the microRNA miR-10a.[4]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA3 homeobox A3". 
  4. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.