HOXA7

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Homeobox A7
Protein HOXA7 PDB 1ahd.png
PDB rendering based on 1ahd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXA7 ; ANTP; HOX1; HOX1.1; HOX1A
External IDs OMIM142950 MGI96179 HomoloGene56001 GeneCards: HOXA7 Gene
RNA expression pattern
PBB GE HOXA7 206847 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3204 15404
Ensembl ENSG00000122592 ENSMUSG00000038236
UniProt P31268 P02830
RefSeq (mRNA) NM_006896 NM_010455
RefSeq (protein) NP_008827 NP_034585
Location (UCSC) Chr 7:
27.19 – 27.2 Mb
Chr 6:
52.21 – 52.22 Mb
PubMed search [1] [2]

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[3]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXA7 homeobox A7". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.