HOXB13

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Homeobox B13
Protein HOXB13 PDB 2cra.png
PDB rendering based on 2cra.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXB13 ; PSGD
External IDs OMIM604607 MGI107730 HomoloGene4640 GeneCards: HOXB13 Gene
RNA expression pattern
PBB GE HOXB13 209844 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10481 15408
Ensembl ENSG00000159184 ENSMUSG00000049604
UniProt Q92826 P70321
RefSeq (mRNA) NM_006361 NM_008267
RefSeq (protein) NP_006352 NP_032293
Location (UCSC) Chr 17:
46.8 – 46.81 Mb
Chr 11:
96.19 – 96.2 Mb
PubMed search [1] [2]

Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.[1][2][3]

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.[3] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.[4]

See also[edit]

References[edit]

  1. ^ Zeltser L, Desplan C, Heintz N (Sep 1996). "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development 122 (8): 2475–84. PMID 8756292. 
  2. ^ Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C (Jul 1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J Invest Dermatol 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387. 
  3. ^ a b "Entrez Gene: HOXB13 homeobox B13". 
  4. ^ Ewing C, et al (Jan 2012). "Germline mutations in HOXB13 and prostate cancer risk". New Engl J Med 366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMID 22236224. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.