HOXB7

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Homeobox B7
Protein HOXB7 PDB 1ahd.png
PDB rendering based on 1ahd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXB7 ; HHO.C1; HOX2; HOX2C; Hox-2.3
External IDs OMIM142962 MGI96188 HomoloGene55828 GeneCards: HOXB7 Gene
RNA expression pattern
PBB GE HOXB7 216973 s at tn.png
PBB GE HOXB7 204778 x at tn.png
PBB GE HOXB7 204779 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3217 15415
Ensembl ENSG00000260027 ENSMUSG00000038721
UniProt P09629 P09024
RefSeq (mRNA) NM_004502 NM_010460
RefSeq (protein) NP_004493 NP_034590
Location (UCSC) Chr 17:
48.61 – 48.63 Mb
Chr 11:
96.29 – 96.29 Mb
PubMed search [1] [2]

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3]

See also[edit]

Interactions[edit]

HOXB7 has been shown to interact with PBX1[4] and CREB-binding protein.[5]

References[edit]

  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ "Entrez Gene: HOXB7 homeobox B7". 
  4. ^ Chang, C P; Shen W F; Rozenfeld S; Lawrence H J; Largman C; Cleary M L (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA-binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74. doi:10.1101/gad.9.6.663. ISSN 0890-9369. PMID 7729685. 
  5. ^ Chariot, A; van Lint C; Chapelier M; Gielen J; Merville M P; Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene (ENGLAND) 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. ISSN 0950-9232. PMID 10435624. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.