HOXB8

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Homeobox B8
Identifiers
Symbols HOXB8 ; HOX2; HOX2D; Hox-2.4
External IDs OMIM142963 MGI96189 HomoloGene7768 GeneCards: HOXB8 Gene
RNA expression pattern
PBB GE HOXB8 221278 at tn.png
PBB GE HOXB8 204778 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3218 15416
Ensembl ENSG00000120068 ENSMUSG00000056648
UniProt P17481 P09632
RefSeq (mRNA) NM_024016 NM_010461
RefSeq (protein) NP_076921 NP_034591
Location (UCSC) Chr 17:
46.69 – 46.69 Mb
Chr 11:
96.28 – 96.29 Mb
PubMed search [1] [2]

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results is a reduction of compulsive grooming.[4]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB8 homeobox B8". 
  4. ^ Shau-Kwaun Chen, Petr Tvrdik, Erik Peden, Scott Cho, Sen Wu1, Gerald Spangrude and Mario R. Capecchi (May 2010). "Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice". Cell 141 (5): 775–785. doi:10.1016/j.cell.2010.03.055. PMC 2894573. PMID 20510925. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.