HOXC10

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Homeobox C10
Identifiers
Symbols HOXC10 ; HOX3I
External IDs OMIM605560 MGI96192 HomoloGene9680 GeneCards: HOXC10 Gene
RNA expression pattern
PBB GE HOXC10 218959 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3226 209448
Ensembl ENSG00000180818 ENSMUSG00000022484
UniProt Q9NYD6 P31257
RefSeq (mRNA) NM_017409 NM_010462
RefSeq (protein) NP_059105 NP_034592
Location (UCSC) Chr 12:
54.38 – 54.38 Mb
Chr 15:
102.97 – 102.97 Mb
PubMed search [1] [2]

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.[1][2]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.[2]

Pathology[edit]

References[edit]

  1. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  2. ^ a b "Entrez Gene: HOXC10 homeobox C10". 
  3. ^ Ansari, K. I.; Hussain, I; Kasiri, S; Mandal, S. S. (2012). "HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4". Journal of Molecular Endocrinology 48 (1): 61–75. doi:10.1530/JME-11-0078. PMID 22143955.  edit
  4. ^ Pathiraja, T. N.; Nayak, S. R.; Xi, Y; Jiang, S; Garee, J. P.; Edwards, D. P.; Lee, A. V.; Chen, J; Shea, M. J.; Santen, R. J.; Gannon, F; Kangaspeska, S; Jelinek, J; Issa, J. P.; Richer, J. K.; Elias, A; McIlroy, M; Young, L. S.; Davidson, N. E.; Schiff, R; Li, W; Oesterreich, S (2014). "Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer". Science Translational Medicine 6 (229): 229ra41. doi:10.1126/scitranslmed.3008326. PMID 24670685.  edit

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.