HOXC8

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Homeobox C8
Identifiers
Symbols HOXC8 ; HOX3; HOX3A
External IDs OMIM142970 MGI96198 HomoloGene130642 GeneCards: HOXC8 Gene
RNA expression pattern
PBB GE HOXC8 221350 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3224 15426
Ensembl ENSG00000037965 ENSMUSG00000001657
UniProt P31273 P09025
RefSeq (mRNA) NM_022658 NM_010466
RefSeq (protein) NP_073149 NP_034596
Location (UCSC) Chr 12:
54.4 – 54.41 Mb
Chr 15:
102.99 – 102.99 Mb
PubMed search [1] [2]

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[1][2][3]


This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[3] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from neurofibromatosis type 1. [4]

See also[edit]

Interactions[edit]

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[5] and Mothers against decapentaplegic homolog 1.[6]

References[edit]

  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXC8 homeobox C8". 
  4. ^ Liu Y (Jan 2014). "Microarray-based identification of nerve growthpromoting genes in neurofibromatosis type I.". J Mol Med Rep 9 (1): 192–6. PMID 24213587. 
  5. ^ Bai, S; Shi X; Yang X; Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. (UNITED STATES) 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. ISSN 0021-9258. PMID 10722652. 
  6. ^ Shi, X; Yang X; Chen D; Chang Z; Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. (UNITED STATES) 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. ISSN 0021-9258. PMID 10224145. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.