HOXD13

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Homeobox D13
Identifiers
Symbols HOXD13 ; BDE; BDSD; HOX4I; SPD
External IDs OMIM142989 MGI96205 HomoloGene20147 GeneCards: HOXD13 Gene
RNA expression pattern
PBB GE HOXD13 207397 s at tn.png
PBB GE HOXD13 207398 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3239 15433
Ensembl ENSG00000128714 ENSMUSG00000001819
UniProt P35453 P70217
RefSeq (mRNA) NM_000523 NM_008275
RefSeq (protein) NP_000514 NP_032301
Location (UCSC) Chr 2:
176.96 – 176.96 Mb
Chr 2:
74.67 – 74.67 Mb
PubMed search [1] [2]

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly and Brachydactyly.[3] The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis.[4]

See also[edit]

References[edit]

  1. ^ Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (February 1990). "The human HOX gene family". Nucleic Acids Res 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. 
  2. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  3. ^ a b "Entrez Gene: HOXD13 homeobox D13". 
  4. ^ Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development 122 (4): 1175–85. PMID 8620844. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.