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Hippocalcin-like 1
Protein HPCAL1 PDB 1bjf.png
PDB rendering based on 1bjf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HPCAL1 ; BDR1; HLP2; VILIP-3
External IDs OMIM600207 MGI1855689 HomoloGene37586 GeneCards: HPCAL1 Gene
RNA expression pattern
PBB GE HPCAL1 212552 at tn.png
PBB GE HPCAL1 205462 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3241 53602
Ensembl ENSG00000115756 ENSMUSG00000071379
UniProt P37235 P62748
RefSeq (mRNA) NM_001258357 NM_016677
RefSeq (protein) NP_001245286 NP_057886
Location (UCSC) Chr 2:
10.44 – 10.57 Mb
Chr 12:
17.69 – 17.79 Mb
PubMed search [1] [2]

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.[1][2][3]

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain.[4] It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.[3]


  1. ^ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222. 
  2. ^ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275. 
  3. ^ a b "Entrez Gene: HPCAL1 hippocalcin-like 1". 
  4. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 

Further reading[edit]