HR (gene)

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Hair growth associated
Identifiers
Symbols HR ; ALUNC; AU; HSA277165; MUHH; MUHH1
External IDs OMIM602302 MGI96223 HomoloGene3774 GeneCards: HR Gene
RNA expression pattern
PBB GE HR 220163 s at tn.png
PBB GE HR 210086 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55806 15460
Ensembl ENSG00000168453 ENSMUSG00000022096
UniProt O43593 Q61645
RefSeq (mRNA) NM_005144 NM_021877
RefSeq (protein) NP_005135 NP_068677
Location (UCSC) Chr 8:
21.97 – 21.99 Mb
Chr 14:
70.55 – 70.57 Mb
PubMed search [1] [2]

Protein hairless is a protein that in humans is encoded by the HR gene.[1][2][3]

This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.[3]

See also[edit]

References[edit]

  1. ^ Ahmad W, Zlotogorski A, Panteleyev AA, Lam H, Ahmad M, ul Haque MF, Abdallah HM, Dragan L, Christiano AM (Apr 1999). "Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family". Genomics 56 (2): 141–8. doi:10.1006/geno.1998.5699. PMID 10051399. 
  2. ^ Nothen MM, Cichon S, Vogt IR, Hemmer S, Kruse R, Knapp M, Holler T, Faiyaz ul Haque M, Haque S, Propping P, Ahmad M, Rietschel M (Apr 1998). "A gene for universal congenital alopecia maps to chromosome 8p21-22". Am J Hum Genet 62 (2): 386–90. doi:10.1086/301717. PMC 1376893. PMID 9463324. 
  3. ^ a b "Entrez Gene: HR hairless homolog (mouse)". 

Further reading[edit]

External links[edit]