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Heparan sulfate 2-O-sulfotransferase 1
Symbols HS2ST1 ; dJ604K5.2
External IDs OMIM604844 MGI1346049 HomoloGene8025 GeneCards: HS2ST1 Gene
EC number 2.8.2.-
Species Human Mouse
Entrez 9653 23908
Ensembl ENSG00000153936 ENSMUSG00000040151
UniProt Q7LGA3 Q8R3H7
RefSeq (mRNA) NM_001134492 NM_011828
RefSeq (protein) NP_001127964 NP_035958
Location (UCSC) Chr 1:
87.38 – 87.6 Mb
Chr 3:
144.43 – 144.57 Mb
PubMed search [1] [2]

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.[1][2]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.[2]


  1. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
  2. ^ a b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1". 

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