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Hydroxysteroid (17-beta) dehydrogenase 8
Protein HSD17B8 PDB 2pd6.png
PDB rendering based on 2pd6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HSD17B8 ; D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1; dJ1033B10.9
External IDs OMIM601417 MGI95911 HomoloGene56588 GeneCards: HSD17B8 Gene
EC number,
RNA expression pattern
PBB GE HSD17B8 213540 at tn.png
More reference expression data
Species Human Mouse
Entrez 7923 14979
Ensembl ENSG00000112474 ENSMUSG00000073422
UniProt Q92506 P50171
RefSeq (mRNA) NM_014234 NM_013543
RefSeq (protein) NP_055049 NP_038571
Location (UCSC) Chr 6:
33.17 – 33.17 Mb
Chr 17:
34.03 – 34.03 Mb
PubMed search [1] [2]

Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.[1][2][3]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.[3]


  1. ^ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499. 
  2. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. 
  3. ^ a b "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8". 

Further reading[edit]