HSF2

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Heat shock transcription factor 2
Identifiers
Symbols HSF2 ; HSF 2; HSTF 2
External IDs OMIM140581 MGI96239 HomoloGene37931 GeneCards: HSF2 Gene
RNA expression pattern
PBB GE HSF2 209657 s at tn.png
PBB GE HSF2 211220 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3298 15500
Ensembl ENSG00000025156 ENSMUSG00000019878
UniProt Q03933 P38533
RefSeq (mRNA) NM_001135564 NM_008297
RefSeq (protein) NP_001129036 NP_032323
Location (UCSC) Chr 6:
122.72 – 122.75 Mb
Chr 10:
57.49 – 57.51 Mb
PubMed search [1] [2]

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[1][2]

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[2]

Interactions[edit]

HSF2 has been shown to interact with Nucleoporin 62[3] and HSF1.[4]

See also[edit]

References[edit]

  1. ^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106. 
  2. ^ a b "Entrez Gene: HSF2 heat shock transcription factor 2". 
  3. ^ Yoshima, T; Yura T; Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. ISSN 0006-291X. PMID 9367915. 
  4. ^ He, Haiying; Soncin Fabrice; Grammatikakis Nicholas; Li Youlin; Siganou Aliki; Gong Jianlin; Brown Steven A; Kingston Robert E; Calderwood Stuart K (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. (United States) 278 (37): 35465–75. doi:10.1074/jbc.M304663200. ISSN 0021-9258. PMID 12813038. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.