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Heat shock 70kDa protein 1A
Protein HSPA1A PDB 1hjo.png
PDB rendering based on 1hjo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HSPA1A ; HEL-S-103; HSP70-1; HSP70-1A; HSP70I; HSP72; HSPA1
External IDs OMIM140550 MGI99517 HomoloGene74294 ChEMBL: 5460 GeneCards: HSPA1A Gene
Species Human Mouse
Entrez 3303 193740
Ensembl ENSG00000204388 ENSMUSG00000091971
UniProt P08107 Q61696
RefSeq (mRNA) NM_005345 NM_010479
RefSeq (protein) NP_005336 NP_034609
Location (UCSC) Chr 6:
31.78 – 31.79 Mb
Chr 17:
34.97 – 34.97 Mb
PubMed search [1] [2]

Heat shock 70 kDa protein 1 is a protein that in humans is encoded by the HSPA1A gene.

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.[1]


HSPA1A has been shown to interact with ASK1,[2] STUB1,[3][4] MSR1,[5] BAG3,[6][7] Parkin (ligase),[4] Fanconi anemia, complementation group C,[8][9] GPR37,[4] HSF1[10][11] and AIFM1.[12][13]

See also[edit]


  1. ^ "Entrez Gene: HSPA1A heat shock 70kDa protein 1A". 
  2. ^ Park, Hee-Sae; Cho Ssang-Goo, Kim Chang Kyun, Hwang Hyun Sub, Noh Kyung Tae, Kim Mi-Sung, Huh Sung-Ho, Kim Myung Jin, Ryoo Kanghyun, Kim Eun Kyung, Kang Woo Jin, Lee Jae-Seon, Seo Jeong-Sun, Ko Young-Gyu, Kim Sunghoon, Choi Eui-Ju (November 2002). "Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1". Mol. Cell. Biol. (United States) 22 (22): 7721–30. doi:10.1128/MCB.22.22.7721-7730.2002. ISSN 0270-7306. PMC 134722. PMID 12391142. 
  3. ^ Ballinger, C A; Connell P; Wu Y; Hu Z; Thompson L J; Yin L Y; Patterson C (June 1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4535–45. ISSN 0270-7306. PMC 104411. PMID 10330192. 
  4. ^ a b c Imai, Yuzuru; Soda Mariko; Hatakeyama Shigetsugu; Akagi Takumi; Hashikawa Tsutomu; Nakayama Kei Ichi; Takahashi Ryosuke (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell (United States) 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. ISSN 1097-2765. PMID 12150907. 
  5. ^ Nakamura, Toshinobu; Hinagata Jun-ichi; Tanaka Toshiki; Imanishi Takeshi; Wada Youichiro; Kodama Tatsuhiko; Doi Takefumi (January 2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors". Biochem. Biophys. Res. Commun. (United States) 290 (2): 858–64. doi:10.1006/bbrc.2001.6271. ISSN 0006-291X. PMID 11785981. 
  6. ^ Doong, H; Price J; Kim Y S; Gasbarre C; Probst J; Liotta L A; Blanchette J; Rizzo K; Kohn E (September 2000). "CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70". Oncogene (ENGLAND) 19 (38): 4385–95. doi:10.1038/sj.onc.1203797. ISSN 0950-9232. PMID 10980614. 
  7. ^ Antoku, K; Maser R S; Scully W J; Delach S M; Johnson D E (September 2001). "Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein". Biochem. Biophys. Res. Commun. (United States) 286 (5): 1003–10. doi:10.1006/bbrc.2001.5512. ISSN 0006-291X. PMID 11527400. 
  8. ^ Pang, Qishen; Christianson Tracy A; Keeble Winifred; Koretsky Tara; Bagby Grover C (December 2002). "The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC". J. Biol. Chem. (United States) 277 (51): 49638–43. doi:10.1074/jbc.M209386200. ISSN 0021-9258. PMID 12397061. 
  9. ^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. (United States) 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622. 
  10. ^ Shi, Y; Mosser D D; Morimoto R I (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes Dev. (UNITED STATES) 12 (5): 654–66. doi:10.1101/gad.12.5.654. ISSN 0890-9369. PMC 316571. PMID 9499401. 
  11. ^ Zhou, X; Tron V A; Li G; Trotter M J (August 1998). "Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light". J. Invest. Dermatol. (UNITED STATES) 111 (2): 194–8. doi:10.1046/j.1523-1747.1998.00266.x. ISSN 0022-202X. PMID 9699716. 
  12. ^ Ruchalski, Kathleen; Mao Haiping; Singh Satish K; Wang Yihan; Mosser Dick D; Li Fanghong; Schwartz John H; Borkan Steven C (December 2003). "HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells". Am. J. Physiol., Cell Physiol. (United States) 285 (6): C1483–93. doi:10.1152/ajpcell.00049.2003. ISSN 0363-6143. PMID 12930708. 
  13. ^ Ravagnan, L; Gurbuxani S, Susin S A, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger J M, Garrido C, Kroemer G (September 2001). "Heat-shock protein 70 antagonizes apoptosis-inducing factor". Nat. Cell Biol. (England) 3 (9): 839–43. doi:10.1038/ncb0901-839. ISSN 1465-7392. PMID 11533664. 

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