HSPB2

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Heat shock 27kDa protein 2
Identifiers
Symbols HSPB2 ; HSP27; Hs.78846; LOH11CR1K; MKBP
External IDs OMIM602179 MGI1916503 HomoloGene68189 GeneCards: HSPB2 Gene
RNA expression pattern
PBB GE HSPB2 205824 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3316 69253
Ensembl ENSG00000170276 ENSMUSG00000038086
UniProt Q16082 Q99PR8
RefSeq (mRNA) NM_001541 NM_001164708
RefSeq (protein) NP_001532 NP_001158180
Location (UCSC) Chr 11:
111.78 – 111.79 Mb
Chr 9:
50.75 – 50.75 Mb
PubMed search [1] [2]

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.[1][2][3]


Interactions[edit]

HSPB2 has been shown to interact with TRAF6,[4] HSPB8,[5][6] Myotonic dystrophy protein kinase[2][7] and CRYAB.[7]

References[edit]

  1. ^ Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (February 1998). "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner". Genomics 45 (2): 386–94. doi:10.1006/geno.1997.4956. PMID 9344664. 
  2. ^ a b Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (April 1998). "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol 140 (5): 1113–24. doi:10.1083/jcb.140.5.1113. PMC 2132705. PMID 9490724. 
  3. ^ "Entrez Gene: HSPB2 heat shock 27kDa protein 2". 
  4. ^ Wu, Yifan; Liu Junhong; Zhang Zhengping; Huang Huang; Shen Jiayin; Zhang Shuangquan; Jiang Yong; Luo Lan; Yin Zhimin (January 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. (England) 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID 18950704. 
  5. ^ Sun, Xiankui; Fontaine Jean-Marc; Rest Joshua S; Shelden Eric A; Welsh Michael J; Benndorf Rainer (January 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. (United States) 279 (4): 2394–402. doi:10.1074/jbc.M311324200. ISSN 0021-9258. PMID 14594798. 
  6. ^ Benndorf, R; Sun X; Gilmont R R; Biederman K J; Molloy M P; Goodmurphy C W; Cheng H; Andrews P C; Welsh M J (July 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. (United States) 276 (29): 26753–61. doi:10.1074/jbc.M103001200. ISSN 0021-9258. PMID 11342557. 
  7. ^ a b Sugiyama, Y; Suzuki A; Kishikawa M; Akutsu R; Hirose T; Waye M M; Tsui S K; Yoshida S; Ohno S (January 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. (UNITED STATES) 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. ISSN 0021-9258. PMID 10625651. 

Further reading[edit]