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Heat shock 27kDa protein 2
Symbols HSPB2 ; HSP27; Hs.78846; LOH11CR1K; MKBP
External IDs OMIM602179 MGI1916503 HomoloGene68189 GeneCards: HSPB2 Gene
RNA expression pattern
PBB GE HSPB2 205824 at tn.png
More reference expression data
Species Human Mouse
Entrez 3316 69253
Ensembl ENSG00000170276 ENSMUSG00000038086
UniProt Q16082 Q99PR8
RefSeq (mRNA) NM_001541 NM_001164708
RefSeq (protein) NP_001532 NP_001158180
Location (UCSC) Chr 11:
111.78 – 111.79 Mb
Chr 9:
50.75 – 50.75 Mb
PubMed search [1] [2]

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.[1][2][3]


HSPB2 has been shown to interact with TRAF6,[4] HSPB8,[5][6] Myotonic dystrophy protein kinase[2][7] and CRYAB.[7]


  1. ^ Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (February 1998). "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner". Genomics 45 (2): 386–94. doi:10.1006/geno.1997.4956. PMID 9344664. 
  2. ^ a b Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (April 1998). "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol 140 (5): 1113–24. doi:10.1083/jcb.140.5.1113. PMC 2132705. PMID 9490724. 
  3. ^ "Entrez Gene: HSPB2 heat shock 27kDa protein 2". 
  4. ^ Wu, Yifan; Liu Junhong; Zhang Zhengping; Huang Huang; Shen Jiayin; Zhang Shuangquan; Jiang Yong; Luo Lan; Yin Zhimin (January 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. (England) 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID 18950704. 
  5. ^ Sun, Xiankui; Fontaine Jean-Marc; Rest Joshua S; Shelden Eric A; Welsh Michael J; Benndorf Rainer (January 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. (United States) 279 (4): 2394–402. doi:10.1074/jbc.M311324200. ISSN 0021-9258. PMID 14594798. 
  6. ^ Benndorf, R; Sun X; Gilmont R R; Biederman K J; Molloy M P; Goodmurphy C W; Cheng H; Andrews P C; Welsh M J (July 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. (United States) 276 (29): 26753–61. doi:10.1074/jbc.M103001200. ISSN 0021-9258. PMID 11342557. 
  7. ^ a b Sugiyama, Y; Suzuki A; Kishikawa M; Akutsu R; Hirose T; Waye M M; Tsui S K; Yoshida S; Ohno S (January 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. (UNITED STATES) 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. ISSN 0021-9258. PMID 10625651. 

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