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Heat shock 22kDa protein 8
Symbols HSPB8 ; CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22
External IDs OMIM608014 MGI2135756 HomoloGene8654 GeneCards: HSPB8 Gene
RNA expression pattern
PBB GE HSPB8 221667 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26353 80888
Ensembl ENSG00000152137 ENSMUSG00000041548
UniProt Q9UJY1 Q9JK92
RefSeq (mRNA) NM_014365 NM_030704
RefSeq (protein) NP_055180 NP_109629
Location (UCSC) Chr 12:
119.62 – 119.66 Mb
Chr 5:
116.41 – 116.42 Mb
PubMed search [1] [2]

Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene.[1][2][3]


HSPB8 has been shown to interact with:


  1. ^ Smith CC, Yu YX, Kulka M, Aurelian L (Sep 2000). "A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells". J Biol Chem 275 (33): 25690–9. doi:10.1074/jbc.M002140200. PMID 10833516. 
  2. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S et al. (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res 60 (21): 5977–83. PMID 11085516. 
  3. ^ "Entrez Gene: HSPB8 Heat shock 22kDa protein 8". 
  4. ^ a b Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R (Jan 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. 279 (4): 2394–402. doi:10.1074/jbc.M311324200. PMID 14594798. 
  5. ^ Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW et al. (Jul 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. 276 (29): 26753–61. doi:10.1074/jbc.M103001200. PMID 11342557. 
  6. ^ Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N et al. (Jun 2004). "Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy". Nat. Genet. 36 (6): 597–601. doi:10.1038/ng1328. PMID 15122253. 

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