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HIV-1 Tat specific factor 1
Protein HTATSF1 PDB 2dit.png
PDB rendering based on 2dit.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HTATSF1 ; TAT-SF1; dJ196E23.2
External IDs OMIM300346 MGI1919709 HomoloGene40950 GeneCards: HTATSF1 Gene
RNA expression pattern
PBB GE HTATSF1 202602 s at tn.png
PBB GE HTATSF1 202601 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27336 72459
Ensembl ENSG00000102241 ENSMUSG00000067873
UniProt O43719 Q8BGC0
RefSeq (mRNA) NM_001163280 NM_028242
RefSeq (protein) NP_001156752 NP_082518
Location (UCSC) Chr X:
135.58 – 135.59 Mb
Chr X:
57.05 – 57.07 Mb
PubMed search [1] [2]

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.[1][2]

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM][2]


HTATSF1 has been shown to interact with SUPT5H[3] and GTF2F2.[3]


  1. ^ Zhou Q, Sharp PA (Nov 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451. 
  2. ^ a b "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1". 
  3. ^ a b Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. (UNITED STATES) 19 (9): 5960–8. ISSN 0270-7306. PMC 84462. PMID 10454543. 

Further reading[edit]