From Wikipedia, the free encyclopedia
Jump to: navigation, search
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Protein HUWE1 PDB 2EKK.png
Rendering based on PDB 2EKK.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HUWE1 ; ARF-BP1; HECTH9; HSPC272; Ib772; LASU1; MULE; URE-B1; UREB1
External IDs OMIM300697 MGI1926884 HomoloGene45994 GeneCards: HUWE1 Gene
RNA expression pattern
PBB GE HUWE1 208598 s at tn.png
PBB GE HUWE1 214673 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10075 59026
Ensembl ENSG00000086758 ENSMUSG00000025261
UniProt Q7Z6Z7 Q7TMY8
RefSeq (mRNA) NM_031407 NM_021523
RefSeq (protein) NP_113584 NP_067498
Location (UCSC) Chr HG1433_PATCH:
53.28 – 53.43 Mb
Chr X:
151.8 – 151.94 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.[1][2][3]


  1. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  2. ^ Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (Nov 2000). "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases". Trends Cell Biol 10 (10): 429–39. doi:10.1016/S0962-8924(00)01834-1. PMID 10998601. 
  3. ^ "Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1". 

Further reading[edit]

External links[edit]