Haemodialysis-associated amyloidosis

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Haemodialysis-associated amyloidosis
Classification and external resources
ICD-10 E85.3
ICD-9 277.3
eMedicine med/3384

Haemodialysis-associated amyloidosis is a form of amyloidosis associated with chronic renal failure.[1]


Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood.[2] It accumulates because it is unable to cross the dialysis filter.

Patients usually present after 5 years of dialysis rarely before that. The tendency of Dialysis associated amyloidosis is to be articular in general affecting the joints.


Low copper dialysis is theorized to prevent or delay onset.[3]

See also[edit]


  1. ^ Miyata T, Oda O, Inagi R, et al. (September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis". J. Clin. Invest. 92 (3): 1243–52. doi:10.1172/JCI116696. PMC 288264. PMID 8376584. 
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0. 
  3. ^ "BU Amyloid Treatment & Research Program".