Hagan Bayley

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hagan Bayley
Born John Hagan Pryce Bayley
(1951-02-13) February 13, 1951 (age 63)[1]
Fields Chemical Biology
Alma mater
Thesis Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (1979)
Doctoral advisor Jeremy Knowles[2]
Doctoral students
  • Lai-Sheung Choi
  • William Hwang
  • Samantha Shanley
  • Shiksha Mantri
  • David Stoddart
  • Gabriel Villar[3]
Known for
Notable awards

(John) Hagan (Pryce) Bayley FRS (born 13 February 1951[1]) is a British Professor of Chemical Biology at the University of Oxford.[6][7][8][9][10]


Bayley was educated at The King's School, Chester,[1] Balliol College, Oxford and Harvard University, where he was awarded a PhD in 1979.[2][11]


Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins,[12] as well as interests in chemical signal transduction and biomolecular materials.[13] He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha hemolysin[14] engineered for sensing has been highly cited.[15]


Following his PhD, Bayley completed postdoctoral research at Massachusetts Institute of Technology, Columbia University, and Texas A&M University.[16] Bayley has been based at the University of Oxford since 2003 and is a fellow of Hertford College, Oxford.[17]

Awards and honours[edit]

Bayley was elected a Fellow of the Royal Society in 2011.[5] His nomination reads

Hagan Bayley's achievements lie at the interface between chemistry and biology. He has used protein chemistry, organic chemistry, and biophysics to explore the folding, assembly, and function of transmembrane channels and pores. These studies have led to the development of protein pores as "nanoreactors", with which both non-covalent and covalent chemistry of single molecules can be examined. Applications of this methodology have included host-guest interactions and step-by-step polymer growth. Based on this work, Bayley has developed "stochastic sensing," which has been shown with a wide variety of analytes to reveal both concentration and identity through single-molecule detection.[5]


  1. ^ a b c d "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who 2014. Who's Who (online edition via Oxford University Press ed.). A & C Black an imprint of Bloomsbury Publishing plc.  (subscription required)
  2. ^ a b Bayley, H.; Knowles, J. R. (1978). "Photogenerated reagents for membrane labeling. 2. Phenylcarbene and adamantylidene formed within the lipid bilayer". Biochemistry 17 (12): 2420–2423. doi:10.1021/bi00605a026. PMID 678520. 
  3. ^ ETHOS: Electronic THeses Online Service via the British Library
  4. ^ Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; Jovanovich, S. B.; Krstic, P. S.; Lindsay, S.; Ling, X. S.; Mastrangelo, C. H.; Meller, A.; Oliver, J. S.; Pershin, Y. V.; Ramsey, J. M.; Riehn, R.; Soni, G. V.; Tabard-Cossa, V.; Wanunu, M.; Wiggin, M.; Schloss, J. A. (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology 26 (10): 1146–1153. doi:10.1038/nbt.1495. PMC 2683588. PMID 18846088. 
  5. ^ a b c http://royalsociety.org/people/hagan-bayley/ Hagan Bayley at the Royal Society
  6. ^ http://bayley.chem.ox.ac.uk/ Bayley group at the University of Oxford
  7. ^ http://research.chem.ox.ac.uk/hagan-bayley.aspx Hagan Bayley Research page
  8. ^ Hagan Bayley from the Scopus bibliographic database.
  9. ^ Braha, O.; Braha, H.; Conlan, L. Q.; Cheley, S.; Bayley, S. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature 398 (6729): 686–690. doi:10.1038/19491. PMID 10227291. 
  10. ^ Lou, H; Chen, M; Black, S. S.; Bushell, S. R.; Ceccarelli, M; Mach, T; Beis, K; Low, A. S.; Bamford, V. A.; Booth, I. R.; Bayley, H; Naismith, J. H. (2011). "Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. Coli". PloS one 6 (10): e25825. doi:10.1371/journal.pone.0025825. PMC 3203869. PMID 22053181. 
  11. ^ Bayley, Hagan (1979). Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (PhD thesis). Harvard University. 
  12. ^ Howorka, S.; Cheley, S.; Bayley, H. (2001). "Sequence-specific detection of individual DNA strands using engineered nanopores". Nature Biotechnology 19 (7): 636–639. doi:10.1038/90236. PMID 11433274. 
  13. ^ Bayley, Hagan Profile at the University of Oxford[dead link]
  14. ^ Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. (1996). "Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore". Science 274 (5294): 1859–1865. doi:10.1126/science.274.5294.1859. PMID 8943190. 
  15. ^ List of publications from Google Scholar
  16. ^ Bayley, H.; Cremer, P. S. (2001). "Stochastic sensors inspired by biology". Nature 413 (6852): 226–230. doi:10.1038/35093038. PMID 11557992. 
  17. ^ Bayley, Hagan Profile at Hertford College