A native of Orlando, Florida, Clinton-Dix spent his freshman and sophomore years at Edgewater High School, where he played running back and was a teammate of Mike Brewster. Before his junior year, Clinton-Dix transferred to Dr. Phillips High School, where, in addition to football, he also lettered in basketball and track, participating in the 4x100m and 4x400m relay. In football, he was an All-American defensive back and kick returner. Named a five-star recruit by Rivals.com, Clinton-Dix was ranked the No. 1 defensive back in his class and sixth-rated player overall. During his senior football season, Clinton-Dix, teamed with All-American running back Dee Hart, led Dr. Phillips to a 14–1 season. The Panthers lost to future-NFL running back Devonta Freeman and Miami Central in the Florida 6A State Championship Game, ending the season ranked #21 nationally by Rivals.com.
Clinton-Dix was one of seven true freshmen that had playing time in 2011 at Alabama. In 2012, he led the team with five interceptions and made seven tackles against Notre Dame in the championship game, one tackle less than C. J. Mosley.
On October 3, 2013, Alabama announced that Clinton-Dix had been suspended indefinitely for unspecified team rules violations. He was reinstated after a 2-game suspension.
On December 2, 2013, Clinton-Dix underwent arthroscopic surgery to repair a torn meniscus in his knee. He finished his junior year with 51 tackles and 2 interceptions. As a junior in 2013, Clinton-Dix was a first-team All-Southeastern Conference (SEC) selection. After the season, he decided to forgo his senior year and enter the 2014 NFL Draft.
Clinton-Dix was selected by the Green Bay Packers as the 21st pick of the first round of the 2014 NFL Draft. On May 29, 2014, he signed a four-year contract roughly worth $8.339 million with a $4.384 million signing bonus. In joining the Packers Clinton-Dix reunited with his former Alabama teammate, running back Eddie Lacy. In Week 3 against the Detroit Lions, Clinton-Dix got his first NFL career interception. Clinton-Dix finished his rookie season 2nd in the team in total tackles with 94.