Halazepam

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Halazepam
Halazepam.svg
Halazepam3d.png
Systematic (IUPAC) name
7-chloro- 5-phenyl- 1-(2,2,2-trifluoroethyl) -1,3-dihydro- 2H-1,4-benzodiazepin- 2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a684001
  •  ?
Legal status
Routes Oral
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic
Half-life 14 hours (drug), 50-100 hours (metabolites).
Excretion Renal
Identifiers
CAS number 23092-17-3 YesY
ATC code N05BA13
PubChem CID 31640
DrugBank DB00801
ChemSpider 29343 YesY
UNII 320YC168LF YesY
KEGG D00338 YesY
ChEMBL CHEMBL970 YesY
Synonyms 9-chloro- 6-phenyl- 2-(2,2,2-trifluoroethyl)- 2,5-diazabicyclo[5.4.0] undeca- 5,8,10,12-tetraen -3-one
Chemical data
Formula C17H12ClF3N2O 
Molecular mass 352.7
 YesY (what is this?)  (verify)

Halazepam is a benzodiazepine derivative that was marketed under the brand names Paxipam in the United States,[1] Alapryl in Spain,[2] and Pacinone in Portugal.[3]

Medical uses[edit]

Halazepam was used for the treatment of anxiety.[medical citation needed]

Adverse effects[edit]

Adverse effects include drowsiness, confusion, dizziness, and sedation. Gastrointestinal side effects have also been reported including dry mouth and nausea.[medical citation needed]

Pharmacokinetics and pharmacodynamics[edit]

Pharmacokinetics and pharmacodynamics were listed in Current Psychotherapeutic Drugs published in June 15, 1998 as follows:[4]

Onset of action Intermediate to slow
Plasma half life 14 hr for parent drug and 30-100 hr for its metabolite
Peak plasma levels 1-3 hr for parent drug and 3-6 hf for its metabolite
Metabolism Metabolized into desmethyldiazepam and 3-hydroxyhalazepam (in the liver)
Excretion Excreted through kidneys
Protein binding 98% bound to plasma protein

Regulatory Information[edit]

Halazepam is classified as a schedule 4 controlled substance with a corresponding code 2762 by the Drug Enforcement Administration (DEA).[5]

Commercial production[edit]

Halazepam was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.[1]

See also[edit]

References[edit]

  1. ^ a b "halazepam". Drugs.com. Retrieved December 11, 2014. 
  2. ^ "Alapryl". Drugs.com. Retrieved December 11, 2014. 
  3. ^ "Pacinone". Drugs.com. Retrieved December 11, 2014. 
  4. ^ Quitkin, Frederick M. ... (1998). Current therapeutic drugs (2nd ed. ed.). Washington: American Psychiatric Press. p. 166. ISBN 0880489944. 
  5. ^ "SCHEDULES OF CONTROLLED SUBSTANCES". Code of Federal Reguations. 2012-04-01. pp. § 1308.14 Schedule IV. Retrieved December 12, 2014. 

External links[edit]