Halazepam

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Halazepam
Halazepam.svg
Halazepam3d.png
Systematic (IUPAC) name
7-chloro- 5-phenyl- 1-(2,2,2-trifluoroethyl) -1,3-dihydro- 2H-1,4-benzodiazepin- 2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a684001
Pregnancy cat.
  •  ?
Legal status
Routes Oral
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic
Half-life 14 hours (drug), 50-100 hours (metabolites).
Excretion Renal
Identifiers
CAS number 23092-17-3 YesY
ATC code N05BA13
PubChem CID 31640
DrugBank DB00801
ChemSpider 29343 YesY
UNII 320YC168LF YesY
KEGG D00338 YesY
ChEMBL CHEMBL970 YesY
Synonyms 9-chloro- 6-phenyl- 2-(2,2,2-trifluoroethyl)- 2,5-diazabicyclo[5.4.0] undeca- 5,8,10,12-tetraen -3-one
Chemical data
Formula C17H12ClF3N2O 
Mol. mass 352.7
 YesY (what is this?)  (verify)

Halazepam[1] is a benzodiazepine derivative and is marketed under the brand names Alapryl and Pacinone It is no longer marketed in the United States. It had been marketed under the name Paxipam, but was withdrawn by its manufacturer, Schering Plough, for poor sales. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoroethyl derivative of nordazepam.[2] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.[3] Halazepam has active benzodiazepine metabolites.[4]

Indications[edit]

Halazepam is indicated for the treatment of anxiety.[5]

See also[edit]

References[edit]

  1. ^ FR Patent 1518382
  2. ^ Greenblatt, D. J.; A. Locniskar and R. I. Shader (June 12, 1982). "Halazepam, another precursor of desmethyldiazepam". Lancet 1 (8285): 1358–9. doi:10.1016/s0140-6736(82)92424-2. PMID 6123659. 
  3. ^ Fann, W. E.; W. M. Pitts and J. C. Wheless (Mar–Apr 1982). "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine". Pharmacotherapy 2 (2): 72–9. PMID 6152591. 
  4. ^ Jochemsen R, Breimer DD (1984). "Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles". Curr Med Res Opin. 8. Suppl 4: 60–79. doi:10.1185/03007998409109545. PMID 6144464. 
  5. ^ Lozano, Lozano, Lozano, et al. (1990). "[Open clinical study of the efficacy and safety of Halazepam in anxiety disorders]". Actas Luso Esp Neurol Psiquiatr Cienc Afines (in Spanish; Castilian) 18 (4): 205–11. PMID 1981637. 

External links[edit]