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Half-life is a mathematical and scientific description of exponential or gradual decay.
Half-life may also refer to:
- Biological half-life, the time it takes for a substance to lose half of its pharmacologic, physiologic, or radiologic activity
- Effective half-life, the effective radioactive half-life in organisms after accounting for excretion
- Half-Life (series), a video game series
- Halflife (comics), the name of two different Marvel comic characters
- Half-Life (novel), a 2004 novel by Aaron Krach
- Half Life (novel), a 2006 novel by Shelley Jackson
- Half Life (3 album), 2001
- Halflife (EP), by Lacuna Coil
- Half-Life E.P., by Local H
- Half Life: A Parable for the Nuclear Age, a 1985 Australian documentary film
- Half-Life (film), a 2008 independent film by Jennifer Phang
- Halflife (Doctor Who), a 2004 BBC Books original novel written by Mark Michalowski
- "Half Life" (Medical Investigation), episode 17 of the first season of Medical Investigation which had a crossover with an episode of Third Watch titled "In the Family Way"
- "Half Life", a song by 10 Years from The Autumn Effect
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