Fluoxymesterone
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| Systematic (IUPAC) name | |
| 9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682690 |
| Pregnancy cat. | X |
| Legal status | Schedule III Controlled Substance |
| Pharmacokinetic data | |
| Bioavailability | 100% Oral |
| Metabolism | Hepatic |
| Half-life | 9.5 hours |
| Excretion | urine |
| Identifiers | |
| CAS number | 76-43-7  |
| ATC code | G03BA01 |
| PubChem | CID 6446 |
| DrugBank | APRD00981 |
| ChemSpider | 6205 |
| UNII | 9JU12S4YFY |
| KEGG | D00327 |
| ChEBI | CHEBI:5120 |
| ChEMBL | CHEMBL1445 |
| Chemical data | |
| Formula | C20H29FO3 |
| Mol. mass | 336.441 g/mol |
| SMILES | eMolecules & PubChem |
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Fluoxymesterone (trade name Halotestin) is an anabolic steroid with strong androgenic properties that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. It is approximately 5 times as potent as methyltestosterone.[citation needed] The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.[citation needed]
Like many C-17 alpha alkylated steroids, Fluoxymesterone (Halotestin) has poor binding to the AR. Even so, its actions are mediated by the androgen receptor, most-likely due to its prolonged plasma half-life.[1]
Fluoxymesterone is only useful to a small select group of athletes who seeks very specific goals.[2] Athletes tend to use it to increase strength and aggression in the gym or in competitions such as strongman contests or fighting (like boxing or mixed martial arts). The lack of estrogenic activity[citation needed] makes fluoxymesterone preffered for pre-fight usage – as weigh-ins would not be affected by water retention. Even in such an events, fluoxymesterone usage is usually limited to mere few weeks rather than cycled like other anabolic steroids for months.[citation needed] It is considered a very toxic oral drug, and a poor choice in most bodybuilding/steroid use applications.[citation needed]
Though the half-life of fluoxymesterone is rumored to be 30–90 minutes, the actual half-life is about 9.2 hours.[citation needed]
Contents |
[edit] Synthesis
[edit] References
- ^ Seth Roberts (2009). Anabolic Pharmacology .
- ^ "Halotestin Steroid". Halotestin.net. http://www.halotestin.net/. Retrieved 14 January 2012.
- ^ Herr, M. E.; Hogg, J. A.; Levin, R. H.; J. Amer. Chem. Soc. 1956, 78, 501.
[edit] Further reading
- Daniels, R. C. (February 1, 2003). The Anabolic Steroid Handbook. Richard C Daniels. p. 80. ISBN 0-9548227-0-6. http://www.amazon.com/Anabolic-Steroid-Handbook-R-Daniels/.
[edit] External links
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