Mandıralı joined Trabzonspor aged 10, and continued on to make his professional debut in 1985, aged 17. He quickly established himself as one of the most consistent finishers of his time. He became a regular in the Turkey national team, and was always near the top of the goalscorers charts. Mandıralı proved his reputation was deserved by scoring many goals in European competition. In all, he scored 23 goals in European football.
Mandıralı was particularly famous for his free-kicks, from which he scored many times in his career. He did not try and curl the ball, like most of his more illustrious colleagues in the art of scoring free-kicks. Instead, he would unleash thunderous shots that would fly past or through walls and leave the goalkeeper standing motionless. In this manner his style is similar with Roberto Carlos.
In 1998, he joined the German club Schalke 04 for DM7 million (€3.5 million), but remained there for one year only. He was transferred back to Trabzonspor in the 1999–2000 season for a sum of €2.25 million. Upon his return, he regained his position as top marksman, consistently ending each season as the club's top scorer. In 2002, he was let go by the chairman Özkan Sümer. There was a good deal of bad feeling about his departure, and it is not widely known what caused the split. Mandıralı moved to Ankaragücü, but did not stay long. He retired soon after, having never won the league championship.