Hammondsville is an unincorporated community in central Saline Township, Jefferson County, Ohio, United States. Although it is unincorporated, it has a post office, with the ZIP code of 43930. It lies along State Route 213. The community is part of the Weirton–Steubenville, WV-OH Metropolitan Statistical Area. Notable residents are Pap "Buckeye" Hogue and Bevo Francis.
Hammondsville is part of the Edison Local School District. Campuses serving the community include Stanton Elementary School (Preschool-Grade 8) and Edison High School  (Grades 9-12).
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Coordinates: 40°33′27″N 80°42′25″W / 40.55750°N 80.70694°W