27 April 1903|
|Died||26 October 1996(aged 93)|
|Citizenship||Germany, Great Britain|
|Nationality||British, German (before 1933)|
|Institutions||University of Aberdeen|
|Alma mater||Humboldt University of Berlin|
|Notable awards||Harvey Prize (1981)
Fellow of the Royal Society (1978)
Hans Walter Kosterlitz FRS(27 April 1903 – 26 October 1996) was a German-born British biologist, who graduated Doctor of Medicine (Dr. med) in Berlin. He settled in Scotland and took a Doctor of Science (DSc) at the University of Aberdeen where he was, for many years, Reader in Physiology.
Kosterlitz is best known for his work on endorphins. He performed a famous experiment that he envisioned in a dream while sleeping. He stimulated a strip of guinea pig intestine electrically and was able to record the contractions with a polygraph. He then found that if you added opiates to the solution, the intestine would not contract. Opiates inhibit intestinal contraction. Those contractions were later found to resume in the presence of both opiates and an antagonist such as naloxone. Later, endogenous endorphins were discovered by applying tissue (pig brain cell homegenate) to the apparatus. This caused the contractions to cease. The degree to which an opiate agonist inhibits contractions in the guinea pig ileum is highly correlated to its potency. Kosterlitz shared the Albert Lasker Award with John Hughes and Solomon Snyder in 1978 for his work in the discovery of the opiate receptors and their natural ligands.
The University of Aberdeen officially opens its new Kosterlitz Centre on 16 September 2010 in memory of Professor Hans Kosterlitz, who joined the University in 1933.
- North, R. A.; Hughes, J. (2013). "Hans Walter Kosterlitz. 27 April 1903 -- 26 October 1996". Biographical Memoirs of Fellows of the Royal Society. doi:10.1098/rsbm.2012.0037.
- Lees, G. M. (1998). "A tribute to the late Hans W. Kosterlitz: Ploughing the lone furrow". Canadian Journal of Physiology and Pharmacology 76 (3): 244–251. doi:10.1139/cjpp-76-3-244. PMID 9673787.
- Hughes, J. (1996). "Hans Kosterlitz (1903–96)". Nature 384 (6608): 418. doi:10.1038/384418a0. PMID 8945465.
- Hughes, J.; Kosterlitz, H. W.; Smith, T. W. (1997). "The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977". British journal of pharmacology 120 (4 Suppl): 428–436; discussion 436–7. doi:10.1111/j.1476-5381.1997.tb06829.x. PMC 3224324. PMID 9142421.
- Henderson, G.; Hughes, J.; Kosterlitz, H. W. (1997). "A new example of a morphine-sensitive neuro-effector junction: Adrenergic transmission in the mouse vas deferens. 1972". British journal of pharmacology 120 (4 Suppl): 396–398; discussion 398–5. doi:10.1111/j.1476-5381.1997.tb06821.x. PMC 3224316. PMID 9142417.
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