|Possible time of origin||11,900 ± 4,800 years before present|
|Possible place of origin|
|Defining mutations||M217, P44, PK2|
|Highest frequencies||Oroqen 61%-91%, Evens 5%-74%, Evenks 44%-71%, Buryats 7%-84%, Mongolians 52%-54%, Kazakhs 40%-60.7%, Tanana 42%, Hazaras 40%, Nivkhs 38%, Koryaks 33%, Daur 31%, Yukaghir 31%, Sibe 27%, Manchu 26%-27%, Altai 22%-24%, Hezhe 22%, Uzbeks 20%, Tujia 18%, Hani 18%, Cheyenne 16%, Apache 15%, Tuvans 15%, Ainu 12.5%-25%, Koreans 13%-16%, 18%  Hui 11%, Sioux 11%, Nogais 14%, Crimean Tatars 9%, Han Chinese 0%-23.5%, Vietnamese 4.3%-12.5%|
|Possible time of origin||3,500 [95% CI 300–19,700] years before present or 2,750 ± 1,370 years before present|
|Possible place of origin||perhaps Mongolia or the Lake Baikal region|
|Defining mutations||M48, M77, M86|
|Highest frequencies||Kazakhs 57%-63%, Oroqen 42%-68%, Evenks 27%-70%, Udegey 60%, Negidal 20%-100%, Evens 5%-61%, Itelmen 39%, Ulchi/Nanai 38%, Kalmyks 37%, Nivkhs 35%, Koryaks 33%, Yukaghir 23%, Mongolians 18%-46% (Uriankhai 33%, Zakhchin 30%, Khalkh 15%, Khoton 10%), Tuvans 7%-20%, Hezhe 11%, Kyrgyz 8%-12%|
In human genetics, Haplogroup C-M217 is a Y-chromosome DNA haplogroup found with greatest frequency in indigenous Siberians (Buryats, Evens, Evenks, Udegeys, etc.), Kazakhs, and Mongolians. Haplogroup C-M217 is the most widespread and frequently occurring branch of the greater Haplogroup C-M130. One particular haplotype within Haplogroup C-M217 has received a great deal of attention for the possibility that it may represent direct patrilineal descent from Genghis Khan. The more convincing explanation is that it was originated from one of many mongolic tribes.
Haplogroup C-M217 is believed to have originated approximately 7,100 to 16,700 years before present in eastern or central Asia. Its closest phylogenetic relatives are found in the general vicinity of South Asia, East Asia, or Oceania.
The extremely broad distribution of Haplogroup C-M217 Y-chromosomes, coupled with the fact that the ancestral paragroup C is not found among any of the modern Siberian or North American populations among whom Haplogroup C-M217 predominates, makes the determination of the geographical origin of the defining M217 mutation exceedingly difficult. The presence of Haplogroup C-M217 at a low frequency but relatively high diversity throughout East Asia and parts of Southeast Asia makes that region one likely source. In addition, the C-M217 haplotypes found with high frequency among North Asian populations appear to belong to a different genealogical branch from the C-M217 haplotypes found with low frequency among East and Southeast Asians, which suggests that the marginal presence of C-M217 among modern East and Southeast Asian populations may not be due to recent admixture from Northeast or Central Asia.
Haplogroup C-M217 is the modal haplogroup among Mongolians and most indigenous populations of the Russian Far East, such as the Northern Tungusic peoples, Koryaks, Itelmens, and Nivkhs. The subclade C-P39 is common among males of the indigenous North American peoples whose languages belong to the Na-Dené phylum. The frequency of Haplogroup C-M217 tends to be negatively correlated with distance from Mongolia and the Russian Far East, but it still comprises more than ten percent of the total Y-chromosome diversity among the Manchus, Koreans, Ainu, and some Turkic peoples of Central Asia although in a genetic study in 2004, haplogroup C-M217 was more frequent among Koreans than previously thought (16.5%). Among the Kazakhs, who are a Turkic people of Kazakhstan and neighboring areas in northern Central Asia, Haplogroup C-M217 once again emerges as the most common haplogroup. Beyond this range of high-to-moderate frequency, which contains mainly the northeast quadrant of Eurasia and the northwest quadrant of North America, Haplogroup C-M217 continues to be found at low frequencies, and it has even been found as far afield as Northwest Europe, Turkey, Pakistan, Nepal and adjacent regions of India, Vietnam, Maritime Southeast Asia, and the Wayuu people of South America.
In Japan, haplogroup C-M217 has been found relatively frequently among Ainus (2/16=12.5% or 1/4=25%) and among Japanese of the Kyūshū region (4/53=7.5% or 8/104=7.7%). In other regional Japanese populations, the frequency of haplogroup C-M217 hovers around 2%.
The frequency of Haplogroup C-M217 in samples of Han Chinese from various areas has ranged from 0% (0/27 Han from Guangxi) to 23.5% (8/34 Han from Xi'an), with the frequency of this haplogroup in several studies' pools of all Han Chinese samples ranging between 6.0% and 12.0%. C-M217 also has been found in samples of minority populations from central and southern China, such as Tujia from Jishou, Hunan (9/49 = 18.4%), Hani (6/34 = 17.6%), Miao (2/58 = 3.4%), She (1/34 = 2.9%), Yao (1/35 = 2.9% from Liannan, Guangdong), Tibetans (4/156 = 2.6%), and Taiwanese aborigines (1/48 = 2.1%).(Karafet 2010)(Xue 2006)(Gayden 2007)
In Vietnam, Haplogroup C-M217 has been found in 12.5% (6/48) of a sample of Vietnamese from Hanoi, Vietnam, 11.8% (9/76) of another sample of Kinh ("ethnic Vietnamese") from Hanoi, Vietnam, 8.5% (5/59) of a sample of Cham people from Binh Thuan, Vietnam, and in 4.3% (3/70) of a sample of Vietnamese from an unspecified location in Vietnam.(Karafet 2010)(He 2012) Haplogroup C-M217 has been found less frequently in other parts of Southeast Asia and nearby areas, including Laos (1/25 = 4.0% Lao from Luang Prabang), Java (1/37 = 2.7%), Nepal (2/77 = 2.6% general population of Kathmandu), Thailand (1/40 = 2.5% Thai, mostly sampled in Chiang Mai), the Philippines (1/48 = 2.1%, 1/64 = 1.6%), and Bali (1/641 = 0.2%).(Gayden 2007)(Karafet 2010)(He 2012)
Although C-M217 is generally found with only low frequency (<5%) in Tibet and Nepal, there may be an island of relatively high frequency of this haplogroup in Meghalaya, India. The indigenous tribes of this state of Northeast India, where they comprise the majority of the local population, speak Khasian languages or Tibeto-Burman languages. A study published in 2007 found C-M217(xM93, P39, M86) Y-DNA in 8.5% (6/71) of a sample of Garos, who primarily inhabit the Garo Hills in the western half of Meghalaya, and in 7.6% (27/353) of a pool of samples of eight Khasian tribes from the eastern half of Meghalaya (6/18 = 33.3% Nongtrai from the West Khasi Hills, 10/60 = 16.7% Lyngngam from the West Khasi Hills, 2/29 = 6.9% War-Khasi from the East Khasi Hills, 3/44 = 6.8% Pnar from the Jaintia Hills, 1/19 = 5.3% War-Jaintia from the Jaintia Hills, 3/87 = 3.4% Khynriam from the East Khasi Hills, 2/64 = 3.1% Maram from the West Khasi Hills, and 0/32 Bhoi from Ri-Bhoi District).(Reddy 2007)
The subclades of Haplogroup C-M217 with their defining mutation(s), according to the 2008 ISOGG tree:
C-M217 Typical of Mongolians, Kazakhs, Buryats, Daurs, Kalmyks, Hazaras, Manchus, Sibes, Oroqens, Koryaks, and Itelmens; with a moderate distribution among other Tungusic peoples, Koreans, Ainus, Han Chinese, Vietnamese, Nivkhs, Altaians, Tuvinians, Uzbeks, Nogais, and Crimean Tatars
C-M77 Typical of Northern Tungusic peoples, Kazakhs, Oirats, Kalmyks, Outer Mongolians, Yukaghirs, Nivkhs, Koryaks, Itelmens, and Udegeys, with a moderate distribution among other Southern Tungusic peoples, Inner Mongolians, Buryats, Tuvinians, Yakuts, Chukchi, Kyrgyz, Uyghurs, Uzbeks, Karakalpaks, and Tajiks
Prior to 2002, there were in academic literature at least seven naming systems for the Y-Chromosome Phylogenetic tree. This led to considerable confusion. In 2002, the major research groups came together and formed the Y-Chromosome Consortium (YCC). They published a joint paper that created a single new tree that all agreed to use. Later, a group of citizen scientists with an interest in population genetics and genetic genealogy formed a working group to create an amateur tree aiming at being above all timely. The table below brings together all of these works at the point of the landmark 2002 YCC Tree. This allows a researcher reviewing older published literature to quickly move between nomenclatures.
|YCC 2002/2008 (Shorthand)||(α)||(β)||(γ)||(δ)||(ε)||(ζ)||(η)||YCC 2002 (Longhand)||YCC 2005 (Longhand)||YCC 2008 (Longhand)||YCC 2010r (Longhand)||ISOGG 2006||ISOGG 2007||ISOGG 2008||ISOGG 2009||ISOGG 2010||ISOGG 2011||ISOGG 2012|
The following research teams per their publications were represented in the creation of the YCC tree.
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- African admixture in Europe
- Genetic genealogy
- Human Y-chromosome DNA haplogroup
- Molecular phylogeny
- Y-chromosome haplogroups by populations
- Y-DNA haplogroups by ethnic groups
- Y-DNA haplogroups by populations of East and Southeast Asia
- Y-DNA haplogroups in Oceanian populations
Y-DNA C subclades
Y-DNA backbone tree
|Evolutionary tree of human Y-chromosome DNA (Y-DNA) haplogroups|
- Tatiana M. Karafet, Ludmila P. Osipova, Marina A. Gubina et al., High Levels of Y-Chromosome Differentiation among Native Siberian Populations and the Genetic Signature of a Boreal Hunter-Gatherer Way of Life, Human Biology, December 2002, v. 74, no. 6, pp. 761–789.
- Yali Xue, Tatiana Zerjal, Weidong Bao, Suling Zhu, Qunfang Shu, Jiujin Xu, Ruofu Du, Songbin Fu, Pu Li, Matthew Hurles, Huanming Yang and Chris Tyler-Smith, Male demography in East Asia: a north-south contrast in human population expansion times, Genetics 172: 2431–2439 (April 2006).
- Karafet, Tatiana, Xu, Liping, Du, Ruofu et al.. "Paternal Population History of East Asia: Sources, Patterns, and Microevolutionary Processes". American Journal of Human Genetics 69 (615–628): 2001.
- Brigitte Pakendorf, Innokentij N. Novgorodov, Vladimir L. Osakovskij, and Mark Stoneking, Mating Patterns Amongst Siberian Reindeer Herders: Inferences From mtDNA and Y-Chromosomal Analyses, American Journal of Physical Anthropology 133:1013–1027 (2007)
- Michael F. Hammer, Tatiana M. Karafet, Hwayong Park, Keiichi Omoto, Shinji Harihara, Mark Stoneking and Satoshi Horai, Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes, Journal of Human Genetics, Volume 51, Number 1 / January, 2006.
- The Dual Origin and Siberian Affinities of Native American Y Chromosomes, Jeffrey T. Lell, Rem I. Sukernik, Yelena B. Starikovskaya, Bing Su, Li Jin, Theodore G. Schurr, Peter A. Underhill, and Douglas C. Wallace, American Journal of Human Genetics 70:192-206, 2002
- Tajima, Atsushi, Hayami, Masanori, Tokunaga, Katsushi, Juji, T, Matsuo, M, Marzuki, S, Omoto, K, Horai, S (2004). "Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages". Journal of Human Genetics 49 (4): 187–193. doi:10.1007/s10038-004-0131-x. PMID 14997363.
- Dulik MC, Osipova LP, Schurr TG (2011) Y-Chromosome Variation in Altaian Kazakhs Reveals a Common Paternal Gene Pool for Kazakhs and the Influence of Mongolian Expansions. PLoS ONE 6(3): e17548. doi:10.1371/journal.pone.0017548
- Stephen L. Zegura, Tatiana M. Karafet, Lev A. Zhivotovsky, and Michael F. Hammer, High-Resolution SNPs and Microsatellite Haplotypes Point to a Single, Recent Entry of Native American Y Chromosomes into the Americas, Molecular Biology and Evolution 21(1):164–175. 2004
- Sengupta S, Zhivotovsky LA, King R, et al. (February 2006). "Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists". Am. J. Hum. Genet. 78 (2): 202–21. doi:10.1086/499411. PMC 1380230. PMID 16400607.
- Brigitte Pakendorf, Innokentij Novgorodov, Vladimir Osakovskij, Albina Danilova, Artur Protodjakonov, and Mark Stoneking, Investigating the effects of prehistoric migrations in Siberia: genetic variation and the origins of Yakuts, Human Genetics, Volume 120, Number 3, October 2006, pp. 334-353(20).
- Zhong, Hua; Shi, Hong; Xue-, XB; Qi, Bin; Jin, L; Ma, RZ; Su, B (2010). "Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia". Journal of Human Genetics 55 (7): 428–35. doi:10.1038/jhg.2010.40. PMID 20448651.
- Soon-Hee Kim, Ki-Cheol Kim, Dong-Jik Shin et al., "High frequencies of Y-chromosome haplogroup O2b-SRY465 lineages in Korea: a genetic perspective on the peopling of Korea," Investigative Genetics 2011, 2:10
- Soon-Hee Kim, Ki-Cheol Kim, Dong-Jik Shin, Han-Jun Jin, Kyoung-Don Kwak, Myun-Soo Han, Joon-Myong Song, Won Kim, and Wook Kim, "High frequencies of Y-chromosome haplogroup O2b-SRY465 lineages in Korea: a genetic perspective on the peopling of Korea," Investigative Genetics 2011, 2:10
- Toru Katoh, Batmunkh Munkhbat, Kenichi Tounai et al., Genetic features of Mongolian ethnic groups revealed by Y-chromosomal analysis, Gene (2004)
- R. Spencer Wells et al., The Eurasian Heartland: A continental perspective on Y-chromosome diversity, Proceedings of the National Academy of Sciences of the United States of America, 28 August 2001; 98(18): 10244–10249.
- Zerjal, Tatiana, Wells, R. Spencer, Yuldasheva, Nadira et al.. "A Genetic Landscape Reshaped by Recent Events: Y-Chromosomal Insights into Central Asia". American Journal of Human Genetics 71 (466–482): 2002.
- Jeffrey T. Lell, Rem I. Sukernik, Yelena B. Starikovskaya, Bing Su, Li Jin, Theodore G. Schurr, Peter A. Underhill and Douglas C. Wallace, The Dual Origin and Siberian Affinities of Native American Y Chromosomes, The American Journal of Human Genetics, Volume 70, Issue 1, 192-206, 1 January 2002.
- Nasidze, Ivan, Quinque, Dominique, Dupanloup, Isabelle et al.. "Genetic Evidence for the Mongolian Ancestry of Kalmyks". American Journal of Physical Anthropology 126: 2005.
- Zerjal et al., The Genetic Legacy of the Mongols (PDF), American Journal of Human Genetics, 2003.
- Gene Flow from the Indian Subcontinent to Australia: Evidence from the Y Chromosome, Alan J. Redd, June Roberts-Thomson et al., Current Biology, 12: 673-677 (April 2002)
- Tenzin Gayden, Alicia M. Cadenas, Maria Regueiro et al., The Himalayas as a Directional Barrier to Gene Flow, American Journal of Human Genetics, Volume 80, May 2007. 2/77=2.6% C-M217 in a sample of the general population of Kathmandu.
- Simona Fornarino, Maria Pala, Vincenza Battaglia et al., Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation, BMC Evolutionary Biology 2009, 9:154. 1/26=3.8% C-M217 in a sample of Hindu Indians from the Terai.
- B. Mohan Reddy, B. T. Langstieh, Vikrant Kumar et al., Austro-Asiatic Tribes of Northeast India Provide Hitherto Missing Genetic Link between South and Southeast Asia, PLoS ONE, Issue 11, November 2007. Haplogroup C-M217 in 8.5% of a sample of 71 Garos and 7.7% of a pool of eight samples of Khasians totalling 353 individuals.
- T. Kivisild, S. Rootsi, M. Metspalu et al., The Genetic Heritage of the Earliest Settlers Persists Both in Indian Tribal and Caste Populations, American Journal of Human Genetics 72:313–332, 2003. C-M217 in 1/31=3.2% of a sample from West Bengal.
- Ivan Nasidze, Dominique Quinque, Isabelle Dupanloup, Richard Cordaux, Lyudmila Kokshunova, and Mark Stoneking, Genetic Evidence for the Mongolian Ancestry of Kalmyks, American Journal of Physical Anthropology 126:000–000 (2005).
- Peter A. Underhill, Peidong Shen, Alice A. Lin et al., Y chromosome sequence variation and the history of human populations, Nature Genetics, Volume 26, November 2000
- V. N. Kharkov, V. A. Stepanov, O. F. Medvedeva, M. G. Spiridonova, N. R. Maksimova, A. N. Nogovitsina, and V. P. Puzyrev, The origin of Yakuts: Analysis of the Y-chromosome haplotypes, Molecular Biology, Volume 42, Number 2 / April, 2008.