Haplogroup K-M9

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Haplogroup K-M9
Possible time of origin 47,000 years BP[1]
Possible place of origin South or West Asia
Ancestor IJK
Descendants K(xLT), and LT
Defining mutations M9, P128, P131, P132

In molecular evolution, a haplogroup (from the Greek: ἁπλούς, haploûs, "onefold, single, simple") is a group of similar haplotypes that share a common ancestor having the same single nucleotide polymorphism (SNP) mutation in all haplotypes. Haplogroup K-M9 (M9) is a Y-chromosome DNA haplogroup. This haplogroup is a descendant of Haplogroup IJK. Its major descendant haplogroup are Haplogroup LT (L298 = P326) and Haplogroup K(xLT) (M526).[2]

Origins[edit]

Y-DNA haplogroup K-M9 is an old lineage established approximately 40,000-50,000 years ago whose origins were probably in Southwestern Asia, South Eastern Asia, or South Asia. At present this group contains two distinct classes of subgroups: 1. Haplogroup LT 2. Haplogroup K(xLT. Today haplogroup K-M9 is only in four states M9, P128, P131, P132. The others are descending mutations are ancestral to the descendant haplogroups (L,M,NO,P,S,T) within haplogroup K-(LT)in addition to that there are also the mutations that define the descendant haplogroups in paragroup K (K1-K4). For more information see the table above for mutations and descendants and see the diagram below for info on descendant haplogroup clads in K-(LT).[3]

Subgroups[edit]


Haplogroup L and T (K2). Spotty with L being found at its highest frequency in Baloch of Afghanistan and western cost of India and Pakistan , while T is most common among: Fulani (Sahelian African), Ethiopans, Somaliland, Djibouti, some alpine cities in Europe, some of the Aegean Islands and a few tribes of India


K2*

K2* 5 cases in Sumatra and 1 case in Sulawesi


NO

X-M147. Highly rare lineage in India. 1 sample found so far.




N Found near Arctic Circle, Yakuts, Finno Ugrians (Ancient samples: Most remains from the Yangshao, Hongshan,Ancient elite Hungarians, Xiongnu and prehistoric Yakuts while the Xiajiadian mixed between O3)



O Sino-Tibetans + modern Longshan and Daxi and Xiajiadian which was divided between N and O3 (Xiajiadian was mixed others were pure) (O3), Austronesians, Polynesians, Melanesians, Malaygasy and in modern Liangzhu to a very low extent (O1), and Austro-Asiatics (O2) dominant east Asian line (O) note O1 and O2 form a clade against O3 called O1'2




K2b
K2b1

M (M-P256*). Found in Papua New Guinea, New Britain, Polynesia , Melanesia but very rare in Australia .



S (S-P405)Found in Papua New Guinea, New Britain and across Melanesia, Australia, but rare in Polynesia (not to be confused with S-P230).



K2b1-P378 Found exclusively in the Aeta who have it at 60%.



K2b1-P336 found at 26% on the Island of Alor found also in other parts of eastern Indonesia at very low frequency



K2b2
P-P295(x45)

35.4 in Tuvans, 28.3% in Altaians-Kizhi, 28% of Aetas, 22.2% in Todjins, 11.8% in Kalmyks, 8.8% in Soyots, 7.6% in Khakas



10% of Timor rare in other parts of Indonesia



P-P295

Q-M242 Kets , Selkups, Turkmen, Altai, Tuvans, Far East Siberia, Americas (Ancient Samples Anzick from Montana, Prehistoric Alaskan + Ancient Greenlander+Xirong, Mongolian Altai Kurgans (R1a-z93 mixed with Q1a2a1-L54) and possibly Afantova.




†R0m* sequence from Mal'ta' in Siberia 24kya y-dna sequence




R2 found in India, Sri Lanka, North Pakistan isolates




R1a found in East Europe, India, Central Asia, Altai, Scandinavia, Uighers Ancient samples include 10 out of 11 samples from Xiaohe Tomb complex, Andronovo, Pazyryk, Mongolian Altai Kurgans (R1a-z93 mixed with Q1a2a1-L54) , The Tagar Culture, Karasuk culture, Tashtyk culture, some Corded ware folk



R1b West Europe, Chadic Langauges, Armenian Highlands (Found in several Bell Beakers from Germany and in late antique Basques of whom it is still common in as well as 13.3% (4):one P probably R1b2-v88: of Guanches from the Canary Islands, (reports of King Tut by iGENEA belonging to R1b have not been verified)









K2c-P261. Minor lineage of Bali.



K2d-P402 Minor lineage of Java



  • Ancient populations haplogroups are assumed from small ancient sample sizes.
    • † Stands for assumed extinction (no living sample of the same haplogroup)
      • [4] Entire Phlogeny except for Hg X + distribution of K2b1 clades K2* clades and K2c+K2d, as well as P(xm45)

[10] [11] [12] [13] [14] [15] [16] [17][18][19][20] Modern Populations+Ancient Basques

References[edit]

  1. ^ Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF (May 2008). "New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree". Genome Res. 18 (5): 830–8. doi:10.1101/gr.7172008. PMC 2336805. PMID 18385274. 
  2. ^ Chiaroni, J.; Underhill, P. A.; Cavalli-Sforza, L. L. (December 2009). "Y chromosome diversity, human expansion, drift, and cultural evolution". Proc. Natl. Acad. Sci. U.S.A. 106 (48): 20174–9. Bibcode:2009PNAS..10620174C. doi:10.1073/pnas.0910803106. JSTOR 25593348. PMC 2787129. PMID 19920170. 
  3. ^ Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF (May 2008). "New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree". Genome Research 18 (5): 830–8. doi:10.1101/gr.7172008. PMC 2336805. PMID 18385274. 
  4. ^ Karafet TM, Mendez FL, Sudoyo H, Lansing JS, Hammer MF (June 2014). "Improved phylogenetic resolution and rapid diversification of Y-chromosome haplogroup K-M526 in Southeast Asia". European Journal of Human Genetics. doi:10.1038/ejhg.2014.106. PMID 24896152. 
  5. ^ Raghavan M, Skoglund P, Graf KE, et al. (January 2014). "Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans". Nature 505 (7481): 87–91. doi:10.1038/nature12736. PMC 4105016. PMID 24256729. 
  6. ^ Rasmussen M, Anzick SL, Waters MR, et al. (February 2014). "The genome of a Late Pleistocene human from a Clovis burial site in western Montana". Nature 506 (7487): 225–9. doi:10.1038/nature13025. PMID 24522598. 
  7. ^ Hollard C, Keyser C, Giscard PH, et al. (September 2014). "Strong genetic admixture in the Altai at the Middle Bronze Age revealed by uniparental and ancestry informative markers". Forensic Science International: Genetics 12: 199–207. doi:10.1016/j.fsigen.2014.05.012. PMID 25016250. 
  8. ^ Fregel R, Gomes V, Gusmão L, et al. (2009). "Demographic history of Canary Islands male gene-pool: replacement of native lineages by European". BMC Evolutionary Biology 9: 181. doi:10.1186/1471-2148-9-181. PMC 2728732. PMID 19650893. 
  9. ^ Grugni V, Battaglia V, Hooshiar Kashani B, et al. (2012). "Ancient migratory events in the Middle East: new clues from the Y-chromosome variation of modern Iranians". Plos One 7 (7): e41252. doi:10.1371/journal.pone.0041252. PMC 3399854. PMID 22815981. 
  10. ^ Haber M, Platt DE, Ashrafian Bonab M, et al. (2012). "Afghanistan's ethnic groups share a Y-chromosomal heritage structured by historical events". PloS One 7 (3): e34288. doi:10.1371/journal.pone.0034288. PMC 3314501. PMID 22470552. 
  11. ^ Bekada A, Fregel R, Cabrera VM, et al. (2013). "Introducing the Algerian mitochondrial DNA and Y-chromosome profiles into the North African landscape". Plos One 8 (2): e56775. doi:10.1371/journal.pone.0056775. PMC 3576335. PMID 23431392. 
  12. ^ Rosser ZH, Zerjal T, Hurles ME, et al. (December 2000). "Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language". American Journal of Human Genetics 67 (6): 1526–43. doi:10.1086/316890. PMC 1287948. PMID 11078479. 
  13. ^ Pichler I, Mueller JC, Stefanov SA, et al. (August 2006). "Genetic structure in contemporary south Tyrolean isolated populations revealed by analysis of Y-chromosome, mtDNA, and Alu polymorphisms". Human Biology 78 (4): 441–64. PMID 17278620. 
  14. ^ Robino C, Varacalli S, Gino S, et al. (October 2004). "Y-chromosomal STR haplotypes in a population sample from continental Greece, and the islands of Crete and Chios". Forensic Science International 145 (1): 61–4. doi:10.1016/j.forsciint.2004.02.026. PMID 15374596. 
  15. ^ Trivedi, R.; Sahoo, Sanghamitra; Singh, Anamika; Bindu, G. Hima; Banerjee, Jheelam; Tandon, Manuj; Gaikwad, Sonali; Rajkumar, Revathi; Sitalaximi, T; Ashma, Richa; Chainy, G. B. N.; Kashyap, V. K. (2007). "High Resolution Phylogeographic Map of Y-Chromosomes Reveal the Genetic Signatures of Pleistocene Origin of Indian Populations". Anthropology Today: Trends, Scope and Applications. 
  16. ^ Hirbo, Jibril Boru (2011). Complex Genetic History of East African Human Populations (PhD Thesis). hdl:1903/11443. [page needed]
  17. ^ http://www.sciencedirect.com/science/article/pii/S0531513103016352[full citation needed]
  18. ^ Cruciani F, Trombetta B, Sellitto D, et al. (July 2010). "Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages". European Journal of Human Genetics 18 (7): 800–7. doi:10.1038/ejhg.2009.231. PMC 2987365. PMID 20051990. 
  19. ^ yhrd.org[full citation needed]
  20. ^ Zhong, Hua; Shi, Hong; Qi, Xue-Bin; Duan, Zi-Yuan; Tan, Ping-Ping; Jin, Li; Su, Bing; Ma, Runlin Z. (2010). "Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route". Molecular Biology and Evolution 28 (1): 717–27. doi:10.1093/molbev/msq247. 
  21. ^ http://www.phylotree.org/Y/tree/index.htm[full citation needed]
  22. ^ Magoon, Gregory R; Banks, Raymond H; Rottensteiner, Christian; Schrack, Bonnie E; Tilroe, Vincent O; Robb, Terry; Grierson, Andrew J (2013). "Generation of high-resolution a priori Y-chromosome phylogenies using 'next-generation' sequencing data". bioRxiv. doi:10.1101/000802. 

External links[edit]


Evolutionary tree of human Y-chromosome DNA (Y-DNA) haplogroups
MRC Y-ancestor
A00 A0'1'2'3'4
A0 A1'2'3'4
A1 A2'3'4
A2'3 A4=BCDEF
A2 A3 B CDEF
DE CF
D E C F
GHIJKLT
G HIJKLT
H IJKLT
IJ KLT (K)
I J LT(K1) K (K2)
L T MPS (K2b) X (K2a)
MS P NO
M S QR N O
Q R
  1. ^ van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.