|Possible time of origin||34.600±4.700 years BP|
|Possible place of origin||South Eastern Asia (South China)|
|Descendants||N, O and NO*|
|Defining mutations||M214, P188, P192, P193, P194, P195.|
In human genetics, Haplogroup NO (M214) is a human Y-chromosome DNA haplogroup. Haplogroup NO is a descendant branch of the greater Haplogroup MNOPS (also known as K(xLT)) and a phylogenetic sibling of Haplogroup M, Haplogroup P, and Haplogroup S.
The M214 mutation that defines Haplogroup NO occurred in a gamete of a man who belonged to Haplogroup K(xLT) and who probably lived somewhere in Asia east of the Aral Sea about 30,000 to 40,000 years ago. This man has become the direct patrilineal ancestor of a very large percentage of present-day humans, as he is the forefather of both Haplogroup N and Haplogroup O, which together are overwhelmingly dominant in most populations of North and East Eurasia.
No confirmed case of Haplogroup NO* has been found. Cases that were thought to be NO* have been found to belong to a new subclade of a widely distrbuted East Asian found at least from Vietnam to Beijing a pre-NO case was found in Southern India and Was labeled haplogroup X, it is possible that NO* exists, but no reason exists to believe it has been found 
This phylogenetic tree of haplogroup subclades is based on the YCC 2008 tree and subsequent published research.
- NO (M214, P188, P192, P193, P194, P195)
|Parts of this article (those related to http://biorxiv.org/content/early/2013/11/22/000802.1 and http://www.phylotree.org/Y/tree/ ) are outdated. (November 2013)|
|Evolutionary tree of human Y-chromosome DNA (Y-DNA) haplogroups|
- Rootsi, Siiri et al. (2007). "A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe". European Journal of Human Genetics 15 (2): 204–211. doi:10.1038/sj.ejhg.5201748. PMID 17149388.
- Karafet, et al. (2008). "Abstract New Binary Polymorphisms Reshape and Increase Resolution of the Human Y-Chromosomal Haplogroup Tree". Genome Research 18 (5): 830–8. doi:10.1101/gr.7172008. PMC 2336805. PMID 18385274.