Haplogroup Q-M120

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Haplogroup Q-M120
Possible time of origin Insufficient Data
Possible place of origin Asia
Ancestor Q-NWT01/F746
Defining mutations M120 and M265 (AKA N14)

In human population genetics, haplogroups define the major lineages of direct paternal (male) lines back to a shared common ancestor in Africa. Haplogroup Q-M120 is a subclade or branch of haplogroup Q-MEH2. The lineage's origin is Asia and it is present in eastern Eurasia.

Distribution[edit]

Q-M120 has descendants in modern populations across eastern Eurasia.

The Americas[edit]

Asia[edit]

Q-M120 is present in Eastern Asia and may trace its origin to East Asia.[1][2] It has been found at low frequency among Han Chinese,[1][2] Dungans,[3] Japanese,[4] Koreans,[3] Uygur,[5] and Tibetans.[2][6] Although it was reported in the Hazaras,[7] it was subsequently shown to be a lab error as demonstrated by the phylogenetic tree changes in Karafet 2008.

Population Paper N Percentage SNP Tested
Dungan (Kyrgyzstan) Wells 2001[3] 3/40 ~7.5% M120
Han (Henan) Su 2000[2] 2/28 ~7.1% M120
Han (Anhui) Su 2000[2] 1/22 ~4.6% M120
Northern Han Su 2000[2] 1/22 ~4.5% M120
Han (Shanghai) Su 2000[2] 1/30 ~3.3% M120
Han (Shandong) Su 2000[2] 1/32 ~3.1% M120
Korea Wells 2001[3] 1/45 ~2.2% M120
Tibetan-Lhasa Su 2000[2] 1/46 ~2.2% M120
Tibet Gayden 2007[6] 2/156 ~1.3% M120
Han (Shanxi) Zhong 2010[5] 1/56 ~1.8% M120
Uygur (Xingjiang) Zhong 2010[5] 1/71 ~1.4% M120
Uygur (Xingjiang) Zhong 2010[5] 1/50 ~2.0% M120
Han (Jiangsui) Su 2000[2] 1/55 ~1.8% M120
Japan Nonaka 2007[4] 1/165 ~0.61% M120

Europe[edit]

To date, Q-M120 has hardly been detected in European populations.

Associated SNPs[edit]

Haplogroup Q-M120 is defined by the presence of the M120 Single Nucleotide Polymorphism (SNP) as well as the M265 (AKA N14) SNP.

Phylogenetic tree[edit]

This is Thomas Krahn at the Genomic Research Center's Draft Tree for haplogroup Q-M120.

  • Q-MEH2 MEH2, L472, L528
    • Q-M120 M120, N14/M265

See also[edit]

Y-DNA Q-M242 subclades[edit]

Y-DNA backbone tree[edit]

Evolutionary tree of human Y-chromosome DNA (Y-DNA) haplogroups
MRC Y-ancestor
A00 A0'1'2'3'4
A0 A1'2'3'4
A1 A2'3'4
A2'3 A4=BCDEF
A2 A3 B CDEF
DE CF
D E C F
GHIJKLT
G HIJKLT
H IJKLT
IJ KLT (K)
I J LT(K1) K (K2)
L T MPS (K2b) X (K2a)
MS P NO
M S QR N O
Q R
  1. ^ van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809. 

References[edit]

  1. ^ a b Wen B; Li H; Lu D et al. (September 2004). "Genetic evidence supports demic diffusion of Han culture". Nature 431 (7006): 302–5. doi:10.1038/nature02878. PMID 15372031. Supplementary Table 2: NRY haplogroup distribution in Han populations 
  2. ^ a b c d e f g h i j Su, Bing; Xiao, Chunjie; Deka, Ranjan; Seielstad, Mark T.; Kangwanpong, Daoroong; Xiao, Junhua; Lu, Daru; Underhill, Peter; Cavalli-Sforza, Luca (2000). "Y chromosome haplotypes reveal prehistorical migrations to the Himalayas". Human Genetics 107 (6): 582–90. doi:10.1007/s004390000406. PMID 11153912. 
  3. ^ a b c d Wells RS; Yuldasheva N; Ruzibakiev R et al. (August 2001). "The Eurasian Heartland: A continental perspective on Y-chromosome diversity". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10244–9. doi:10.1073/pnas.171305098. PMC 56946. PMID 11526236. Table 1: Y-chromosome haplotype frequencies in 49 Eurasian populations, listed according to geographic region 
  4. ^ a b Nonaka, I.; Minaguchi, K.; Takezaki, N. (2007). "Y-chromosomal Binary Haplogroups in the Japanese Population and their Relationship to 16 Y-STR Polymorphisms". Annals of Human Genetics 71 (4): 480–95. doi:10.1111/j.1469-1809.2006.00343.x. PMID 17274803. 
  5. ^ a b c d Zhong, H.; Shi, H.; Qi, X.-B.; Duan, Z.-Y.; Tan, P.-P.; Jin, L.; Su, B.; Ma, R. Z. (2010). "Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route". Molecular Biology and Evolution 28 (1): 717–27. doi:10.1093/molbev/msq247. PMID 20837606. 
  6. ^ a b Gayden T; Cadenas AM; Regueiro M et al. (May 2007). "The Himalayas as a Directional Barrier to Gene Flow". Am. J. Hum. Genet. 80 (5): 884–94. doi:10.1086/516757. PMC 1852741. PMID 17436243. 
  7. ^ Sengupta, Sanghamitra; Zhivotovsky, Lev A.; King, Roy; Mehdi, S.Q.; Edmonds, Christopher A.; Chow, Cheryl-Emiliane T.; Lin, Alice A.; Mitra, Mitashree; Sil, Samir K. (2006). "Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists". The American Journal of Human Genetics 78 (2): 202–21. doi:10.1086/499411. PMC 1380230. PMID 16400607. 

External links[edit]