Haplogroup R0 (mtDNA)

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Haplogroup R0
Possible time of origin 23,600 to 54,900 YBP[1]
Possible place of origin Near East or South Asia
Ancestor R
Descendants HV, R0a
Defining mutations 73, 11719[2]

In human mitochondrial genetics, Haplogroup R0 (formerly known as Haplogroup pre-HV[3]) is a mitochondrial DNA (mtDNA) haplogroup.

Origin[edit]

Haplogroup R0 derives from the macro-haplogroup R. It is an ancestral haplogroup to R0a and Haplogroup HV (and therefore to Haplogroup H and Haplogroup V).

Distribution[edit]

Haplogroup R0 occurs frequently in the Arabian Plate with its highest frequency in Socotri (Population 50,000 Yemen) 38% [4] and its also found in a high frequency in the Kalash (Population 6,000 in Pakistan) with 23%[5] smaller frequency in North Africa, the Horn of Africa, Anatolia, Iranian Plateau & Dalmatia. Its greater variety in the Arabian Plate suggests R0a originated in and spread from there.

Subclades[edit]

Tree[edit]

This phylogenetic tree of haplogroup R0 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.

  • R
    • R0 or pre-HV
      • R0a or (preHV)1
        • R0a1 or (preHV)1a
          • R0a1a
        • 60.1T
          • R0a2 or (preHV)1b
            • R0a2a
            • R0a2b
            • R0a2c
            • R0a2d
            • R0a2e
        • HV
          • HV0
          • HV1
          • 73
          • HV4
          • HV5
          • H

See also[edit]

Evolutionary tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M N  
CZ D E G Q   A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References[edit]

  1. ^ Soares, P; Ermini, L; Thomson, N; Mormina, M; Rito, T; Röhl, A; Salas, A; Oppenheimer, S et al. (2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". American Journal of Human Genetics 84 (6): 740–59. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773. 
  2. ^ a b van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. Retrieved 2009-05-20. 
  3. ^ Haplogroup H Sub-clades, Family Tree DNA
  4. ^ Viktor Cerny et al. 2008, Out of Arabia—The Settlement of Island Soqotra as Revealed by Mitochondrial and Y Chromosome Genetic Diversity.
  5. ^ Quintana-Murci, Lluís et al. (2004). "Where West Meets East: The Complex mtDNA Landscape of the Southwest and Central Asian Corridor.". American Journal of Human Genetics 74: 2004. doi:10.1086/383236. 

External links[edit]