Haploidisation is the process of halving the chromosomal content of a cell, creating a haploid cell. Within the normal reproductive cycle, haploidisation is one of the major functional consequences of meiosis, the other being a process of chromosomal crossover that mingles the genetic content of the parental chromosomes. Haploidisation commitment is a checkpoint in yeast meiosis that does not occur at 34 C in the temperature-sensitive cdc5-1 mutant strain, which follows the successful completion of premeiotic DNA replication and recombination commitment.
Usually, haploidisation creates a monoploid cell from a diploid progenitor, or it can involve halving of a polyploid cell, for example to make a diploid potato plant from a tetraploid lineage of potato plants.
If haploidisation is not followed by fertilisation, the result is a haploid lineage of cells. For example, experimental haploidisation may be used to recover a strain of haploid Dictyostelium from a diploid strain.
Haploidisation sometimes occurs naturally in plants when meiotically reduced cells (usually egg cells) develop by parthenogenesis.
- ML Kothari, L Mehta (2002). "Bipolar hermaphroditism of somatic cell as the basis of its being and becoming: celldom appreciated.". Journal of Postgraduate Medicine.
- PMID 1981
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