Brodkey was raised in University City, Missouri outside St. Louis. After graduating from Harvard University in 1952, Brodkey began his writing career by contributing short stories to The New Yorker and other magazines. His stories have won him two first-place O. Henry Awards. In 1993 Brodkey announced in The New Yorker that he had contracted AIDS. He later wrote This Wild Darkness about his battle with the disease. At the time of his death in 1996, he was living in New York City with his wife, novelist Ellen Brodkey (née Schwamm).
Brodkey is most famous for his long-awaited novel A Party of Animals, which was eventually published (perhaps only in part) as The Runaway Soul (1991).
Brodkey's career began promisingly with the short story collection First Love and Other Sorrows, which received widespread critical praise at the time of its 1958 publication. Soon thereafter, in 1964, Brodkey signed a book contract with Random House for his first novel, titled A Party of Animals (it was also referred to as The Animal Corner). The unfinished novel was subsequently resold to Farrar, Straus & Giroux in 1970, and later to Knopf in 1979. During this period, Brodkey published a number of stories, most of them in the New Yorker, that dealt with a set of recurring characters—the evidently autobiographical Wiley Silenowicz and his adoptive family—and which were announced as fragments of the novel. His editor at Knopf, Gordon Lish, called the novel in progress "the one necessary American narrative work of this century." Literary critic Harold Bloom declared "If he's ever able to solve his publishing problems, he'll be seen as one of the great writers of his day."
In addition to publishing, Brodkey earned a living during this period by writing television pilot scripts for NBC, and teaching at Cornell University. Three long stories from A Party of Animals were collected in Women and Angels (1985), and a larger number (including those three) in 1988's Stories in an Almost Classical Mode. Evidently Brodkey had decided to omit them from the novel, for when in 1991 he published The Runaway Soul, a very long (835-page) novel dramatizing Wiley's early life, no material from Stories in an Almost Classical Mode was included. The novel seems to be either A Party of Animals under a new title or the first volume of an eventual multi-volume work. Brodkey made some comments that suggested the latter, but no further material was published in his lifetime, or has been since.
From the beginning of his career, Brodkey accrued detractors. Reviewing First Love for The Christian Science Monitor, Melvin Maddocks wrote that "a sense of vital, untampered-with conflict is missing. These stories seem too patly, too cautiously worked out. They are Japanese-garden fiction with every pebble in place.” A critic for The Atlantic Monthly similarly complained that Brodkey “appears to be the kind of artist committed to working in the minor key which The New Yorker has made fashionable.”
Kirkus Reviews called Stories in an Almost Classical Mode an "endless kvetch." In The New Criterion, Bruce Bawer found the book's tone to be "extraordinarily arrogant and self-obsessed." He further wrote, “Brodkey is so fixated upon the tragic memories of his childhood and youth that he has virtually no sense of proportion about them. In one story after another, he offers up pages of gratuitous detail, straining, it seems, to squeeze every last drop of significance out of every last inane particular.” Later, in assessing The Runaway Soul, Bawer wrote, “The plain fact is that 99 percent of the prose here is gawky, aimless, repetitive, murky, and pretentious—and there are few more unenviable literary experiences than having to read over eight hundred pages of it.” He concluded that the novel was "one of the literary fiascos of all time."
“Entering The Runaway Soul,” wrote Christopher Lehmann-Haupt in The New York Times, “is like arriving at a monthlong house party and being accosted at the door by your host, who sticks his mouth in your face and begins to talk.” Lehmann-Haupt found the book to be replete with “bogus philosophizing” and “paradoxical non-art," with prose that was "verbose, repetitive, overstuffed with adverbs, of questionable sense, tedious and just plain ugly".
Regarding This Wild Darkness, Brenda Bracker in The Baltimore Sun criticized the “long and self-indulgent stretches of the author’s much-touted mystical prose” and wrote that “watching Brodkey watch himself die by inches becomes, ultimately, tedious.” 
Short story collections
- First Love and Other Sorrows (1958, ISBN 0-8050-6010-3)
- Stories in an Almost Classical Mode (1988, ISBN 0-679-72431-1)
- The World is the Home of Love and Death (1997), ISBN 0-8050-5999
- This Wild Darkness: The Story of My Death (1996, ISBN 0-8050-4831-6)
- My Venice (1998, ISBN 0-8050-4833-2)
- Sea Battles on Dry Land: Essays (1999, ISBN 0-8050-6052-9)
- Dinitia Smith (January 27, 1996). "Harold Brodkey, 65, New Yorker Writer And Novelist, Dies of Illness He Wrote About". The New York Times.
- Newsweek, November 18, 1991.
- Time, November 25, 1991.
- "an endless kvetch". https://www.kirkusreviews.com/book-reviews/harold-brodkey-2/stories-in-an-almost-classical-mode/#review
- Lehmann-Haupt, Christopher (November 11, 1991). "Books of The Times; Long in the Making, a Long Book About One Mind". The New York Times.
|This article needs additional citations for verification. (October 2010)|
- Jonathan Baskin, "Fading Fast," Bookforum
- Harold Brodkey resources on the Web
- "People: Harold Brodkey", The New York Times
- James Linville (Winter 1991). "Harold Brodkey, The Art of Fiction No. 126". Paris Review.