Harry Powlett, 4th Duke of Bolton PC (24 July 1691 – 9 October 1759), known until 1754 as Lord Harry Powlett, was a British nobleman and Whig politician, the second son of Charles Paulet, 2nd Duke of Bolton and Frances Ramsden. He sat in the House of Commons from 1715 to 1754, when he took his seat in the House of Lords.
During the close of the War of the Spanish Succession, he served as an ADC to the Earl of Galway in Portugal, in 1710.
He married Catherine Parry (d. 25 April 1744), by whom he had four children:
He was elected at the 1715 general election as a Member of Parliament (MP) for St Ives in Cornwall. He held the seat until the 1722 general election, when he was returned as MP for Hampshire. He held that seat until he succeeded to the peerage in 1754, with one interruption. At the 1734 general election he was returned both for Hampshire and for Yarmouth. A petition was lodged against the Hampshire result, and he sat for Yarmouth until 1737 when the petition against the Hampshire result was withdrawn, then chose to represent Hampshire rather than Yarmouth for the remainder of the Parliament.
From 1733 until 1742, he was a Lord of the Admiralty. He was sworn a Privy Counsellor in 1755.