The song was the first song written by Hiatt following his sobriety from drugs and alcohol which had already contributed to his marriage breakdown and his being released by former record labels.
The original attempt at recording the song took place at a friend's studio and included a larger instrument accompaniment however the recording was plagued by technical issues. The morning after, Hiatt was informed that his estranged wife had committed suicide. Hiatt attributes the technical problems with the original recording as a sign that the song was not meant to be heard that way and he eventually released the song much more simply with a piano accompaniment.
"Have a Little Faith in Me" is the first single from the fourth studio album from Mandy Moore, Coverage. Moore has publicly admitted the original song to be one of her favorites. In 2004, the label included "Have a Little Faith in Me" in the first compilation of Mandy Moore, The Best of Mandy Moore. Later, in 2007, included the single in the deluxe edition of the second artist compilation album, Super Hits.
The music video for "Have a Little Faith in Me" was directed by Christopher Mills, with whom Moore worked for the first time in the race, the video stream is different from his previous videos, you can see Moore wearing elegant clothes, and other scenes with a common picture, you can also observe that it takes a hair color darker tone that previously used.
"Have a Little Faith in Me" did not have a major impact in the United States, reaching the No. 39 position radial count Pop Songs. As the date, "Have a Little Faith in Me" has sold 1,000 physical copies and 45,000 paid digital downloads according to Nielsen Soundscan.
"Have a Little Faith in Me" was covered by Maisy Stella (as Daphne Conrad) and Will Chase (as Luke Wheeler) in the third season of the television show Nashville. The song was performed on episode 19 "The Storm Has Just Begun." It was released as a single and included on the album The Music of Nashville: Season 3, Volume 2.