PTPN7

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Protein tyrosine phosphatase, non-receptor type 7
Protein PTPN7 PDB 1zc0.png
PDB rendering based on 1zc0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PTPN7 ; BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI
External IDs OMIM176889 MGI2156893 HomoloGene15411 ChEMBL: 2219 GeneCards: PTPN7 Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE PTPN7 204852 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5778 320139
Ensembl ENSG00000143851 ENSMUSG00000031506
UniProt P35236 Q8BUM3
RefSeq (mRNA) NM_001199797 NM_177081
RefSeq (protein) NP_001186726 NP_796055
Location (UCSC) Chr 1:
202.12 – 202.13 Mb
Chr 1:
135.13 – 135.15 Mb
PubMed search [1] [2]

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

Interactions[edit]

PTPN7 has been shown to interact with MAPK3[3][4][5] and MAPK1.[3][5]

References[edit]

  1. ^ Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y et al. (September 1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem Biophys Res Commun 186 (3): 1607–15. doi:10.1016/S0006-291X(05)81592-X. PMID 1510684. 
  2. ^ a b "Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7". 
  3. ^ a b Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794. 
  4. ^ Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. 
  5. ^ a b Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983. 

Further reading[edit]

  • Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y et al. (1992). "Protein-tyrosine phosphatase expression in pre-B cell NALM-6". Cancer Res. 52 (3): 737–40. PMID 1370651. 
  • Zanke B, Suzuki H, Kishihara K, Mizzen L, Minden M, Pawson A et al. (1992). "Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase)". Eur. J. Immunol. 22 (1): 235–9. doi:10.1002/eji.1830220134. PMID 1530918. 
  • Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995). "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP". J. Biol. Chem. 270 (37): 21902–6. doi:10.1074/jbc.270.37.21902. PMID 7545170. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Zanke B, Squire J, Griesser H, Henry M, Suzuki H, Patterson B et al. (1994). "A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1". Leukemia 8 (2): 236–44. PMID 8309248. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Saxena M, Williams S, Gilman J, Mustelin T (1998). "Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 273 (25): 15340–4. doi:10.1074/jbc.273.25.15340. PMID 9624114. 
  • Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983. 
  • Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A et al. (1999). "Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase". J. Immunol. 163 (3): 1282–8. PMID 10415025. 
  • Saxena M, Williams S, Taskén K, Mustelin T (1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. 
  • Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794. 
  • Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M et al. (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933. 
  • Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H et al. (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759. 
  • Wang ZX, Zhou B, Wang QM, Zhang ZY (2002). "A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity". Biochemistry 41 (24): 7849–57. doi:10.1021/bi025776m. PMID 12056917. 
  • Digilio MC, Conti E, Sarkozy A, Mingarelli R, Dottorini T, Marino B et al. (2002). "Grouping of Multiple-Lentigines/LEOPARD and Noonan Syndromes on the PTPN11 Gene". Am. J. Hum. Genet. 71 (2): 389–94. doi:10.1086/341528. PMC 379170. PMID 12058348. 
  • Kosaki K, Suzuki T, Muroya K, Hasegawa T, Sato S, Matsuo N et al. (2002). "PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome". J. Clin. Endocrinol. Metab. 87 (8): 3529–33. doi:10.1210/jc.87.8.3529. PMID 12161469. 
  • Pettiford SM, Herbst R (2003). "The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells". Leukemia 17 (2): 366–78. doi:10.1038/sj.leu.2402767. PMID 12592337.