Hemagglutinin-neuraminidase

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Hemagglutinin-neuraminidase
PDB 1usr EBI.jpg
Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase.[1]
Identifiers
Symbol HN
Pfam PF00423
Pfam clan CL0434
InterPro IPR000665
SCOP 1usr
SUPERFAMILY 1usr

Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and neuraminidase activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins.

However it does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure.[2]

Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary.

Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including Mumps virus, Human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.

Types include:

Hemagglutinin-neuraminidase inhibitors have been investigated and suggest that there may applications for human use in the future.[3]

References[edit]

  1. ^ Zaitsev V, von Itzstein M, Groves D, et al. (April 2004). "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion". J. Virol. 78 (7): 3733–41. doi:10.1128/JVI.78.7.3733-3741.2004. PMC 371092. PMID 15016893. 
  2. ^ Lawrence MC, Borg NA, Streltsov VA, et al. (January 2004). "Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III". J. Mol. Biol. 335 (5): 1343–57. doi:10.1016/j.jmb.2003.11.032. PMID 14729348. 
  3. ^ Alymova IV, Taylor G, Takimoto T, et al. (May 2004). "Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo". Antimicrob. Agents Chemother. 48 (5): 1495–502. doi:10.1128/AAC.48.5.1495-1502.2004. PMC 400544. PMID 15105096.