Hematidrosis (also called hematohidrosis) is a very rare condition in which a human sweats blood. It may occur when a person is suffering extreme levels of stress, for example, facing his or her own death. Several historical references have been described; notably by Leonardo da Vinci: describing a soldier who sweated blood before battle, men unexpectedly given a death sentence, as well as descriptions in the Bible, that Jesus experienced hematidrosis when he was praying in the garden of Gethsemane (Luke 22:43-44).
There are a few names and conditions which may pertain to this, such as hematochromatosis, or staining of tissues with blood pigment. Hemochromatosis a disorder due to deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary. Other clinical signs include bronze pigmentation of skin, arthropathy, diabetes, cirrhosis, hepatosplenomegaly, hypogonadism, and loss of body hair. Full development of the disease among women is restricted by menstruation and pregnancy.
There are varying degrees of hemochromatosis, as described below.
Genetic, hereditary, and idiopathic hemochromatosis
An autosomal recessive disorder of iron metabolism associated with a gene tightly linked to the A locus of the human leukocyte antigens (HLA). complex on chromosome 6; iron accumulation is lifelong, with symptoms appearing usually in the fifth or sixth decades of life.
Neonatal and perinatal hemochromatosis
A rare fulminant disease of the liver, of unknown cause, characterized by massive deposition of iron in the liver, pancreas, heart, and endocrine glands; symptoms are those of neonatal hepatitis and appear in utero or within the first week of life, with death usually occurring by 4 months of age.