Henry Wax Karnes (September 8, 1812 – August 16, 1840) was notable as a soldier and figure of the Texas Revolution, as well as the commander of General Sam Houston's "Spy Squad" at the Battle of San Jacinto.
Karnes was buried outside of Old Campo Santos Cemetery as he was a Protestant and only Catholics were allowed to be buried there. This cemetery was later moved and Santa Rosa Hospital was built in its place across from Milam Park. A monument to Karnes was erected in 1932 in Milam Park as this was the closest to his grave that the city knew of. The monument remains there to this day.