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Virus classification
Group: Group IV ((+)ssRNA)
Family: Flaviviridae
Genus: Hepacivirus
Type species
Hepatitis C virus

Canine hepacivirus
Guereza hepacivirus
Hepatitis C virus
Rodent hepacivirus

Hepacivirus is a genus of the Flaviviridae family of viruses. The type species is Hepatitis C virus (HCV). Hepaciviruses, like other Flaviviridae, infect mammals.


HCV, which is the causative agent of the hepatitis C in humans and the type species of the genus, was discovered in 1989.[1]

GBV-B virus (also known as GB virus B) discovered in 1995 is capable of infecting New World monkeys, in particular tamarins. Like HCV it is transmitted by the blood-borne route and similar to HCV it is associated with the viral hepatitis. However GBV-B has never been identified in wild animals and its natural host is not known.[1]

Rodent hepacivirus is found in the deer mouse (Peromyscus maniculatus).[1]

Additional hepaciviruses have been described from bats, rodents including bank voles, horses and dogs.[2][3][4]

Cattle also appear to be a host for these viruses.[5]


  1. ^ a b c Stapleton, J. T.; Foung, S.; Muerhoff, A. S.; Bukh, J.; Simmonds, P. (2010). "The GB viruses: A review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae". Journal of General Virology 92 (2): 233–46. doi:10.1099/vir.0.027490-0. PMC 3081076. PMID 21084497.  edit
  2. ^ Kapoor A, Simmonds P, Scheel TK, Hjelle B, Cullen JM, Burbelo PD, Chauhan LV, Duraisamy R, Sanchez Leon M, Jain K, Vandegrift KJ, Calisher CH, Rice CM, Lipkin WI (2013) Identification of rodent homologs of hepatitis C virus and pegiviruses. MBio 4(2):e00216-13. doi: 10.1128/mBio.00216-13
  3. ^ Drexler JF, Corman VM, Müller MA, Lukashev AN, Gmyl A, Coutard B, Adam A, Ritz D, Leijten LM, van Riel D, Kallies R, Klose SM, Gloza-Rausch F, Binger T, Annan A, Adu-Sarkodie Y, Oppong S, Bourgarel M, Rupp D, Hoffmann B, Schlegel M, Kümmerer BM, Krüger DH, Schmidt-Chanasit J, Setién AA, Cottontail VM, Hemachudha T, Wacharapluesadee S, Osterrieder K, Bartenschlager R, Matthee S, Beer M, Kuiken T, Reusken C, Leroy EM, Ulrich RG, Drosten C (2013) Evidence for novel hepaciviruses in rodents. PLoS Pathog 9(6):e1003438
  4. ^ Lauck M, Sibley SD, Lara J, Purdy MA, Khudyakov Y, Hyeroba D, Tumukunde A, Weny G, Switzer WM, Chapman CA, Hughes AL, Friedrich TC, O'Connor DH, Goldberg TL (2013) A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate. J Virol
  5. ^ Corman VM, Grundhoff A, Baechlein C, Fischer N, Gmyl A, Wollny R, Dei D, Ritz D, Binger T, Adankwah E, Marfo KS, Annison L, Annan A, Adu-Sarkodie Y, Oppong S, Becher P, Drosten C, Drexler JF10. Highly divergent hepaciviruses from African cattle. J Virol 89(11):5876-82. doi: 10.1128/JVI.00393-15.

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