From Wikipedia, the free encyclopedia
Jump to: navigation, search
Virus classification
Group: Group IV ((+)ssRNA)
Family: Hepeviridae
Genus: Hepevirus

Hepatitis E virus
Rat hepatitis E virus

Hepevirus is a viral genus assigned to the Hepeviridae family. This genus is not to be confused with the Herpesvirus family. Hepevirus is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric[disambiguation needed] capsids with a diameter of 27–34 nm. The type species is Hepatitis E virus.[1]


The Hepevirus genome is 7176 nucleotides long and it infects vertebrates. Additionally, the genome is monopartite, and linear ssRNA (+). The genome is 5' capped with a poly A tail at the 3' end. There are three main open reading frames are encoded by the Hepevirus genome. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein.


Viruses from this family have been isolated from birds and bats.[2][3] The creation of new genera within this family to accommodate these viruses seems likely. At least three genospecies of hepatitis E like viruses have been isolated from birds.[4]

A Hepatitis E like virus has been isolated from a Swedish moose.[5] This virus is quite distinct from the other known Hepatitis E viruses.


  1. ^ ICTVdB Management (2006). Hepevirus. In: ICTVdB—The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA
  2. ^ Drexler JF, Seelen A, Corman VM, Fumie Tateno A, Cottontail V, Melim Zerbinati R, Gloza-Rausch F, Klose SM, Adu-Sarkodie Y, Oppong SK, Kalko EK, Osterman A, Rasche A, Adam A, Müller MA, Ulrich RG, Leroy EM, Lukashev AN, Drosten C (2012) Bats worldwide carry hepatitis E-related viruses that form a putative novel genus within the family Hepeviridae. J Virol
  3. ^ Marek A, Bilic I, Prokofieva I, Hess M (2010) Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes. Vet Microbiol 145(1–2):54–61
  4. ^ Zhao Q, Sun Y, Zhou E (2012) Detection and description of avian hepatitis E virus isolated in China—a review. Wei Sheng Wu Xue Bao 52(3):279–825
  5. ^ Lin J, Norder H, Uhlhorn H, Belák S, Widén F (2013) Novel Hepatitis E like virus found in Swedish moose. J Gen Virol doi: 10.1099/vir.0.059238-0

External links[edit]