|Group:||Group IV ((+)ssRNA)|
Hepevirus is a viral genus assigned to the Hepeviridae family. This genus is not to be confused with the Herpesvirus family. Hepevirus is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric[disambiguation needed] capsids with a diameter of 27–34 nm. The type species is Hepatitis E virus.
The Hepevirus genome is 7176 nucleotides long and it infects vertebrates. Additionally, the genome is monopartite, and linear ssRNA (+). The genome is 5' capped with a poly A tail at the 3' end. There are three main open reading frames are encoded by the Hepevirus genome. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein.
Viruses from this family have been isolated from birds and bats. The creation of new genera within this family to accommodate these viruses seems likely. At least three genospecies of hepatitis E like viruses have been isolated from birds.
A Hepatitis E like virus has been isolated from a Swedish moose. This virus is quite distinct from the other known Hepatitis E viruses.
- ICTVdB Management (2006). 00.084.0.01. Hepevirus. In: ICTVdB—The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA
- Drexler JF, Seelen A, Corman VM, Fumie Tateno A, Cottontail V, Melim Zerbinati R, Gloza-Rausch F, Klose SM, Adu-Sarkodie Y, Oppong SK, Kalko EK, Osterman A, Rasche A, Adam A, Müller MA, Ulrich RG, Leroy EM, Lukashev AN, Drosten C (2012) Bats worldwide carry hepatitis E-related viruses that form a putative novel genus within the family Hepeviridae. J Virol
- Marek A, Bilic I, Prokofieva I, Hess M (2010) Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes. Vet Microbiol 145(1–2):54–61
- Zhao Q, Sun Y, Zhou E (2012) Detection and description of avian hepatitis E virus isolated in China—a review. Wei Sheng Wu Xue Bao 52(3):279–825
- Lin J, Norder H, Uhlhorn H, Belák S, Widén F (2013) Novel Hepatitis E like virus found in Swedish moose. J Gen Virol doi: 10.1099/vir.0.059238-0
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