Hereditary breast–ovarian cancer syndrome

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Ovarian and breast cancer patients in a pedigree chart of a family

Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual suffered from both, or several individuals in the pedigree suffered from one or the other disease). The hereditary factors may be proven or suspected to cause the pattern of breast and ovarian cancer occurrences in the family.[1]

Hereditary causes[edit]




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Approximate proportion of hereditary breast cancer cases caused by each gene

  BRCA1 mutations (28%)
  BRCA2 mutations (19%)
  All other known genes (8%)
  Unknown genes or multiple genes (45%)

Multiple genes are associated with HBOC.[2]

BRCA mutations are the most common of the known genes.[2] Harmful mutations in the BRCA1 and BRCA2 genes can produce very high rates of breast and ovarian cancer, as well as increased rates of other cancers.

Other identified genes include:

Approximately 45% of HBOC cases involve unidentified genes, or multiple genes.[2]

Footnotes[edit]

  1. ^ "Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2)". Stanford University. Retrieved 2008-09-02. 
  2. ^ a b c d e f g h i j Morris, Joi L.; Gordon, Ora K. (Ora Karp) (2010). Positive results : making the best decisions when you're at high risk for breast or ovarian cance. Amherst, N.Y.: Prometheus Books. pp. 337–340. ISBN 978-1-59102-776-8. 

External links[edit]