Herpes simplex virus protein vmw65

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Alpha trans-inducing protein (Alpha-TIF)
PDB 16vp EBI.jpg
Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.[1]
Identifiers
Symbol Alpha_TIF
Pfam PF02232
InterPro IPR003174
SMART SM00814
SCOP 16vp
SUPERFAMILY 16vp

Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.[3][4]

References[edit]

  1. ^ Liu Y, Gong W, Huang CC, Herr W, Cheng X (July 1999). "Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16". Genes Dev. 13 (13): 1692–703. doi:10.1101/gad.13.13.1692. PMC 316849. PMID 10398682. 
  2. ^ Entry for Vmw65 on Cure hunter
  3. ^ O'Reilly D, Hanscombe O, O'Hare P (May 1997). "A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II". EMBO J. 16 (9): 2420–30. doi:10.1093/emboj/16.9.2420. PMC 1169842. PMID 9171355. 
  4. ^ Wysocka J, Herr W (June 2003). "The herpes simplex virus VP16-induced complex: the makings of a regulatory switch". Trends Biochem. Sci. 28 (6): 294–304. doi:10.1016/S0968-0004(03)00088-4. PMID 12826401.