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CAS number 137295-60-4
UniProt P02877

Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.[2]

The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.

It has antifungal properties.[3]

Role of hevein in latex allergy[edit]

Hevein is the main IgE-binding epitope of the major latex allergen prohevein[4] as are hevein-like protein domains in fruit class I chitinases.[5] Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes.[6] Hevein-like genes can be found in many plants including Arabidopsis thaliana.[7]

The conformational epitope on hevein is called Hev b 6.02.[8][9]


  1. ^ Broekaert, I; Lee, HI; Kush, A; Chua, NH; Raikhel, N (1990). "Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis)". Proceedings of the National Academy of Sciences of the United States of America 87 (19): 7633–7. doi:10.1073/pnas.87.19.7633. PMC 54802. PMID 2217194. 
  2. ^ Gidrol, X; Chrestin, H; Tan, HL; Kush, A (1994). "Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is involved in the coagulation of latex". The Journal of Biological Chemistry 269 (12): 9278–83. PMID 8132664. 
  3. ^ Parijs, Jan; Broekaert, Willemf.; Goldstein, Irwinj.; Peumans, Willyj. (1991). "Hevein: An antifungal protein from rubber-tree (Hevea brasiliensis) latex". Planta 183 (2). doi:10.1007/BF00197797. 
  4. ^ Alenius, H; Kalkkinen, N; Reunala, T; Turjanmaa, K; Palosuo, T (1996). "The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43-amino acid fragment, hevein". Journal of immunology (Baltimore, Md. : 1950) 156 (4): 1618–25. PMID 8568268. 
  5. ^ Dìaz-Perales, A; Sánchez-Monge, R; Blanco, C; Lombardero, M; Carillo, T; Salcedo, G (2002). "What is the role of the hevein-like domain of fruit class I chitinases in their allergenic capacity?". Clinical and experimental allergy 32 (3): 448–54. doi:10.1046/j.1365-2222.2002.01306.x. PMID 11940077. 
  6. ^ Diaz-Perales, A; Collada, C; Blanco, C; Sánchez-Monge, R; Carrillo, T; Aragoncillo, C; Salcedo, G (1998). "Class I chitinases with hevein-like domain, but not class II enzymes, are relevant chestnut and avocado allergens". The Journal of allergy and clinical immunology 102 (1): 127–33. doi:10.1016/s0091-6749(98)70063-6. PMID 9679856. 
  7. ^ Potter, S; Uknes, S; Lawton, K; Winter, AM; Chandler, D; Dimaio, J; Novitzky, R; Ward, E; Ryals, J (1993). "Regulation of a hevein-like gene in Arabidopsis". Molecular plant-microbe interactions : MPMI 6 (6): 680–5. doi:10.1094/mpmi-6-680. PMID 8118053. 
  8. ^ Reyes-López, CA; Hernández-Santoyo, A; Pedraza-Escalona, M; Mendoza, G; Hernández-Arana, A; Rodríguez-Romero, A (2004). "Insights into a conformational epitope of Hev b 6.02 (hevein)". Biochemical and Biophysical Research Communications 314 (1): 123–30. doi:10.1016/j.bbrc.2003.12.068. PMID 14715255. 
  9. ^ Pedraza-Escalona, Martha; Becerril-Luján, Baltazar; Agundis, Concepción; Domínguez-Ramírez, Lenin; Pereyra, Ali; Riaño-Umbarila, Lidia; Rodríguez-Romero, Adela (2009). "Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies". Molecular Immunology 46 (4): 668–76. doi:10.1016/j.molimm.2008.08.282. PMID 18930549. 

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