Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties. [1 ]
It is available for use topically on small
skin infections, or as an ingredient in throat lozenges. Also Johnson & Johnson markets hexylresorcinol in its Neutrogena and RoC skincare products as an anti-aging cream.
A study published in
Chemical Research in Toxicology shows that 4-hexylresorcinol used as a food additive (E-586) exhibits some estrogenic activity, i.e. resembles action of the female sex hormone [2 ] estrogen.
In one study, 4-hexylresorcinol increased the
shelf life of shrimp by reducing melanosis (black spots). [3 ]
In mice with cancer, 4-hexylresorcinol inhibited
NF-κB and extended their survival rate. [4 ]
References [ edit ]
^ O. Gisvold (1966). C. O. Wilson, O. Gisvold and R. F. Doerge, ed. Textbook of Organic Medicinal and Pharmaceutical Chemistry (5th ed.). Philadelphia: Lippincott. pp. 237–262.
^ Amadasi, A; Mozzarelli, A; Meda, C; Maggi, A; Cozzini, P (2009). "Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach". Chem. Res. Toxicol. 22 (1): 52–63. doi: 10.1021/tx800048m. PMC 2758355. PMID 19063592.
^ Montero, P. (2006). "Effectiveness of Onboard Application of 4-Hexylresorcinol in Inhibiting Melanosis in Shrimp (Parapenaeus longirostris)". Journal of Food Science. doi: 10.1111/j.1365-2621.2004.tb09913.x.
^ Kim, Seong-Gon (2011). "4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells". Oncology Report.