Hidradenoma

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Hidradenoma
Classification and external resources
Nodular hidradenoma - intermed mag.jpg
Micrograph showing an acrospiroma. H&E stain.

Hidradenoma(also known as acrospiroma, from akral "peripheral" + spiroma "epithelial tumor of sweat gland") refers to a benign adnexal tumor of the apical sweat gland. [1][2] It usually presents as a single, small skin-colored lesion, and is considered distinct from the closely related poroma. Hidradenomas are often sub-classified based on subtle histologic differences, for example:

  • clear-cell hidradenoma or acrospiroma
  • nodular hidradenoma or acrospiroma
  • solid-cystic hidradenoma

Discussion of sweat gland tumors can be difficult and confusing due to the complex classification and redundant terminology used to describe the same tumors. For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe benign sweat gland tumors. In addition, a single lesion may contain a mixture of cell-types.[2] There has also been a change in understanding about how tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands.[3][4]

Hidradenomas are by definition benign, with malignant transformation very rare. When tumors show malignant characteristics, they are known as hidradenocarcinoma.[5] Surgical excision is usually curative and local recurrences are rare, although malignant tumors may metastasize.[3]

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  1. ^ Laws RA, English JC 3rd, Elston DM (1996). "Acrospiroma: a case report and review". Cutis 58 (5): 349–51. PMID 8934076. 
  2. ^ a b Obaidat NA, Alsaad KO, Ghazarian D (February 2007). "Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands". J. Clin. Pathol. 60 (2): 145–59. doi:10.1136/jcp.2006.041608. PMC 1860616. PMID 16882695. 
  3. ^ a b Griffiths, C; Cox, N; Breathnach, S et al., eds. (2010). "53. Tumours of the Skin Appendages: Eccrine or aprocrine/follicular tumours". Rook's Textbook of Dermatology - 8th Ed. Chichester, West Sussex: John Wiley & Sons Ltd. ISBN 1-4051-6169-8. 
  4. ^ Griffiths, C; Cox, N; Breathnach, S et al., eds. (2010). "53. Tumours of the Skin Appendages: Eccrine gland tumours". Rook's Textbook of Dermatology - 8th Ed. Chichester, West Sussex: John Wiley & Sons Ltd. ISBN 1-4051-6169-8. 
  5. ^ Hernandez, PE; Cestoni, PR (1985). "Nodular hidradenoma and hidradenocarcinoma. J Am Acad Dermatol 1985; 12: 15-20.". J Am Acad Dermatol 12: 15–20. doi:10.1016/s0190-9622(85)70002-3.