Highway 60 begins at U.S. Route 65 Business in Conway. It runs west for 1.5 miles (2.4 km) and intersects with spur route 60. It continues west for 5.5 miles (8.9 km) until it reaches the County Line at the overpass of Toad Suck Ferry Lock and Dam. Highway 60 then continues to run west for 7.7 miles (12.4 km) and meets with Highway 113. It continues west for 3.8 miles (6.1 km) with Highway 113 and meets the northern terminus of Highway 216 in Houston.
0.1 miles (0.16 km) west of Highway 216, Highway 113 splits off from highway 60. Highway 60 then runs west for 6.5 miles (10.5 km) to Perryville where it intersects with Highway 9. Both highways follow the same path south in Perryville for 0.3 miles (0.48 km) where they diverge. Highway 60 then runs west for 10.8 Miles to where it intersects with the northern terminus of Highway 177. It then runs west for another 10.1 miles (16.3 km) until it intersects with Arkansas Highway 7. It then crosses Highway 7 and runs west 1.6 miles (2.6 km) to the county line.
From the county line, Highway 60 runs west 7.0 miles (11.3 km) to terminate at Highway 28. Along this route it passes by Nimrod Lake.