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Symbols HPCA ; BDR2
External IDs OMIM142622 MGI1336200 HomoloGene55634 GeneCards: HPCA Gene
Species Human Mouse
Entrez 3208 15444
Ensembl ENSG00000121905 ENSMUSG00000028785
UniProt P84074 P84075
RefSeq (mRNA) NM_002143 NM_001130419
RefSeq (protein) NP_002134 NP_001123891
Location (UCSC) Chr 1:
33.35 – 33.36 Mb
Chr 4:
129.11 – 129.12 Mb
PubMed search [1] [2]

Hippocalcin is a protein that in humans is encoded by the HPCA gene.[1][2]

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[3][4] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.[5]


Hippocalcin takes part in the following processes:


Hippocalcin interacts with following proteins:

  • Neuronal apoptosis inhibitory protein (NAIP)
  • Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
  • The b2 adaptin of the AP2 complex
  • Calcium-dependent activator protein for secretion (CADPS)


  1. ^ Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID 8166736. 
  2. ^ Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID 9931466. 
  3. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005. 
  4. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. 
  5. ^ O'Callaghan DW, Tepikin AV, Burgoyne R D (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC 2173692. PMID 14638856. 

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